LOS ANGELES — Seth Rogen and Zac Efron have bested the web-slinger at the box office.

Rogen and Efron’s family-versus-fraternity comedy “Neighbors,” was the top draw for moviegoers this weekend, unseating last week’s champ, “The Amazing Spider-Man 2.”

“Sustaining a No. 1 ranking is generally tougher in the summer than any other time of year,” said Paul Dergarabedian, senior media analyst for box-office tracker Rentrak. “You don’t expect a comedy to be able to unseat an epic blockbuster, but historically it happens more than you think.”

R-rated comedies have traditionally found success in the summer movie season: Think “Bridesmaids,” “The Hangover,” 2012’s “Ted” and last year’s “The Heat.”

“Neighbors” stars Rogen and Rose Byrne as new parents finding their footing in the suburbs when a fraternity led by Efron moves in next door.

Estimated ticket sales for Friday through Sunday at U.S. and Canadian theaters:

1. “Neighbors,” $51 million

2. “The Amazing Spider-Man 2,” $37.2 million

3. “The Other Woman,” $9.25 million

4. “Heaven Is for Real,” $7 million.

5. “Captain America: The Winter Soldier,” $5.6 million

6. “Rio 2,” $5.1 million

7. “Moms’ Night Out,” $4.2 million

8. “Legends of Oz,” $3.7 million

9. “Divergent,” $1.7 million

10. “Brick Mansions,” 1.3 million.