Jim Kelly has another cancer battle on his hands.

The Hall of Fame quarterback and 1978 graduate of East Brady High School has been diagnosed with a recurrence of oral cancer.

Doctors at Erie County Medical Center in Buffalo, N.Y., found the cancer during follow-up testing of Kelly, the Associated Press reported.

Dave Kerschbaumer, who went to school at East Brady with Kelly and his brothers and knows the family well, said he learned the news Tuesday.

He said Kelly, 54, is already in a New York City hospital receiving treatment.

“He’s been through this before,” Kerschbaumer said. “Like everything he takes on in life, he’s taking this on head on. He has a great support system with his family and friends. Family always comes first with Jim.”

Kelly’s wife, Jill, took to Twitter to thank concerned fans of her husband.

“We are overwhelmed by the sincere love you have shown and continue to extend to our family,” she wrote.

Kelly’s eldest daughter, Erin, a student at Liberty University in Virginia, also tweeted, “He’s a Kelly. He’ll never give up! Thank you to everyone who continues to pray for my dad. We believe ...”

Kelly was first diagnosed with squamous cell carcinoma in his upper jaw in June.

When doctors discovered the cancer, it had not spread to other parts of his body and was surgically removed.

Chemotherapy and radiation treatment was not needed. It is unknown what treatment options Kelly has with this second battle with cancer in less than a year.

In a visit to Karns City High School in October as part of the NFL’s Hometown Hall of Famers program, Kelly spoke of the challenges he faced recuperating from his cancer treatment and other physical ailments.

“The last two years, I’ve had major back surgery, double hernia surgery, neck surgery and three jaw surgeries before they found out I had cancer,” Kelly said. “I’ve been through the ringer.”

In October, Kelly also spoke of his frustration with the slow recovery, even though he looked healthy and strong in his gold Hall of Fame jacket.

“It’s getting there,” he said. “Interior and exterior are two different things. It takes time.”

Now, it appears, Kelly is waging another physical battle.

On the football field, Kelly was known for his toughness, leading the Buffalo Bills to four consecutive Super Bowls, only to feel the sting of defeat all four times.

He was inducted into the Pro Football Hall of Fame in 2002.

He retired in 1996 after an 11-year career with the Bills.

Kelly also fought a battle on another front for his son, Hunter, who was born with a rare nervous system disorder called Krabbe disease.

Kelly formed the Hunter’s Hope Foundation, which raised money for research to find a cure for Hunter’s illness.

Given just three years to live, Hunter died in 2005 at the age of 8.

Kerschbaumer wondered just how many more obstacles Kelly would have to face in his life.

“Life keeps kicking him down,” Kerschbaumer said, “but he keeps getting back up. His faith will help him through this. He always finds a way to pull things out. With as much tragedy as he’s gone through, he still has a great outlook on life. He’ll get back up again.”