CHARLOTTE, N.C. — Cam Newton threw three touchdown passes and ran for another, and Carolina sacked Eli Manning seven times as the Panthers handed Tom Coughlin his worst defeat as coach of the New York Giants, 38-0 Sunday.

It was the largest margin of victory in Panthers history.

Colts 27, 49ers 7

SAN FRANCISCO — Andrew Luck threw for 164 yards and ran for a 6-yard touchdown while facing college coach Jim Harbaugh for the first time, and Indianapolis defeated San Francisco.

Trent Richardson scored a 1-yard touchdown on his first carry in his Colts debut after being acquired on Wednesday from the Browns. He was drafted two spots behind Luck at No. 3 last year.

Patriots 23, Bucs 3

FOXBOROUGH, Mass. — Tom Brady threw two touchdown passes to Kenbrell Thompkins to lead New England to a one-sided win over Tampa Bay.

Thompkins, an undrafted free agent, scored on plays of 16 and 5 yards in the first half. Aaron Dobson, a second-round draft pick, finished with seven catches for 52 yards.

Bengals 34, Packers 30

CINCINNATI — Terence Newman returned a fumble 58 yards for a touchdown with 3:47 left, rallying Cincinnati past Green Bay in a game of wild momentum swings set up by nonstop turnovers.

Each team gave it away four times. Each team returned a fumble for a touchdown — M.D. Jennings ran one back for Green Bay (1-2). The Bengals blew a 14-point lead, and the Packers let a 16-point lead get away in the second half.

Saints 31, Cardinals 7

NEW ORLEANS — Drew Brees passed for three scores and scrambled for New Orleans’ first touchdown rushing of the season in a victory over Arizona.

The Saints quarterback was 29 of 46 for 342 yards, with two TD strikes to tight end Jimmy Graham and the other to Robert Meachem.

Cowboys 31, Rams 7

ARLINGTON, Texas — DeMarco Murray ran for 175 yards and a touchdown two years after torching St. Louis with a franchise record as a rookie, and Tony Romo threw for three scores in Dallas’ rout.

Murray had his first 100-yard game in more than a year.

The Cowboys (2-1) sacked Sam Bradford four times in the first half and had six overall after St. Louis (1-2) hadn’t allowed a sack in four games, dating to last season.

Ravens 30, Texans 9

BALTIMORE — Daryl Smith had a 37-yard interception return for a TD, Tandon Doss took a punt 82 yards for another score, and Baltimore smothered Houston’s high-powered offense.

The Ravens (2-1) won despite playing without Ray Rice for the first time since 2008. The three-time Pro Bowl running back was replaced by Bernard Pierce, who ran for 65 yards and a touchdown.

Lions 27, Redskins 20

LANDOVER, Md. — Matthew Stafford completed 25 of 42 passes for 385 yards with two touchdowns and one interception, and Calvin Johnson and Nate Burleson both had 100 yards receiving for Detroit, which beat Washington on the road for the first time.

Titans 20, Chargers 17

NASHVILLE, Tenn. — Jake Locker helped Tennessee end a skid against the San Diego that spanned two states and two decades.

Locker threw a 34-yard touchdown pass to rookie Justin Hunter with 15 seconds left and the Titans rallied to beat the Chargers.

Browns 31, Vikings 27

MINNEAPOLIS — Jordan Cameron caught three touchdown passes, including the go-ahead grab in the back of the end zone with 51 seconds left, and Cleveland kept Minnesota winless.

Third-stringer Brian Hoyer threw for three scores for the Browns (1-2), the latest team to torch Minnesota’s depleted secondary. He overcame three interceptions to throw for 321 yards, going 30 for 54. Josh Gordon had 10 catches for 146 yards and a touchdown in his season debut, and Cameron had six receptions for 66 yards.

Seahawks 45, Jags 17

SEATTLE — Russell Wilson matched his career high with four touchdown passes — two each to Sidney Rice and Zach Miller — and Seattle overwhelmed Jacksonville.

The Seahawks improved to 3-0 for the first time since 2006, beginning a stretch of four straight games against the AFC South.

Dolphins 27, Falcons 23

MIAMI GARDENS, Fla. — Ryan Tannehill lobbed a 1-yard touchdown pass to rookie Dion Sims with 38 seconds left, and unbeaten Miami rallied past Atlanta.

The score capped a 13-play, 75-yard drive after Atlanta’s Matt Bryant missed a 35-yard field goal attempt with 4:46 left. Jimmy Wilson intercepted Matt Ryan to seal the victory.

Jets 27, Bills 20

EAST RUTHERFORD, N.J. — Geno Smith threw two touchdown passes, including a go-ahead 69-yarder to Santonio Holmes in the fourth quarter, and the New York Jets overcame a team-record 20 penalties to hang on and beat Buffalo in an ugly game.