INDIANAPOLIS — Coach Rick Pitino enjoyed watching Friday night's game almost as much as his Louisville players enjoyed celebrating.

Fun-loving forward Terrence Williams danced on the sideline. Guard Edgar Sosa posed for the television camera. Even backup Kyle Kuric dunked. For the top-seeded team in the NCAA tournament, this was more fun than a team scrimmage or a pickup game.

Earl Clark scored 19 points and had nine rebounds and the Cardinals delivered one of the most crushing blowouts in regional history with a 103-64 victory over Arizona.

"We played great tonight because we really passed the ball beautifully," Pitino said. "It's fun as a coach to watch the guys be so unselfish."

Should they follow the same script Sunday, against second-seeded Michigan State in the Midwest final, the Cardinals (31-5) will return to the Final Four for the first time since 2005. The Spartans beat Kansas, the defending champs, 67-62 in the second semifinal game.

But if they play like this, they could fulfill another goal: Winning their third national championship.

The Big East now has four teams playing in this weekend's regional finals, including its regular-season and tournament champ, Louisville. Pitino improved to 9-0 all-time in the regional semifinals.

Louisville was incredibly efficient in the highest-scoring game in its NCAA tournament history, shooting 57.6 percent from the field and dishing out 29 assists on 38 baskets. It shot 48 percent on 3-pointers and grabbed nearly as many offensive rebounds (11) as Arizona had on defense (17).

It was by far the Cardinals' biggest rout in their long NCAA tournament history and easily the Wildcats' most-lopsided loss.

For Arizona (21-14), the lowest seed to reach the semis at No. 12, it was an embarrassing end to a turbulent season. There was a coaching change in October, a 2-5 start in Pac-10 play and the Wildcats lost five of their last six regular-season game, putting the nation's longest active streak of consecutive tourney appearances in jeopardy.

Yet the committee still took them, for the 25th straight year, as one of the final at-large teams in the 65-team field. For two games, it looked like the committee made the right call as Arizona beat Utah and Cleveland State in Miami.

On Friday, though, Louisville demonstrated just how wide the disparity between a 1 seed and a 12 seed can be.

Chase Budinger led Arizona with 22 points, and Jordan Hill had 14 points and 11 rebounds. But Arizona shot 38 percent from the field, and never had a chance after the opening minutes.

Oklahoma 84, Syracuse 71

MEMPHIS, Tenn. — Oklahoma is dangerous enough with Blake Griffin. Give him some help? The Sooners are nearly unstoppable.

Griffin scored 30 points and had 14 rebounds, and Tony Crocker added a career-high 28 points as the second-seeded Sooners beat Syracuse 84-71 Friday night and advanced to their first regional final since 2003.

The last time the Sooners (30-5) made it this far, Syracuse beat them en route to their own national championship.

The Orange (28-10) finally ran out of the magic that helped them pull off such wins as their six-overtime marathon over Connecticut in the Big East tournament.

Michigan St. 67, Kansas 62

INDIANAPOLIS — Goran Suton scored 20 points and Michigan State was steady from the foul line, defeating the defending NCAA champion Jayhawks in the Midwest Regional semifinals.

Kalin Lucas added 18 points for the Spartans (29-6).

Sherron Collins scored 20 points and Cole Aldrich had 17 points and 14 rebounds for Kansas (27-7).

N. Carolina 98, Gonzaga 77

MEMPHIS, Tenn. — Flawless at the start and composed throughout, Ty Lawson and North Carolina breezed to another regional final.

Lawson scored 17 of his 19 points in the first half, and the top-seeded Tar Heels routed Gonzaga 98-77 in the South Regional on Friday night. They'll play second-seeded Oklahoma Sunday for a berth in the Final Four.