LOUISVILLE, Ky. — No. 20 Pittsburgh caught Louisville at the wrong time as the 21st-ranked Cardinals rebounded from a bad outing. Now, the Panthers are hoping they have a similar response after losing 59-41 Thursday night.

“They came out aggressive, physical,” said forward Michael Young, who led the Panthers with 18 points and eight rebounds. “They really got after us coming off a loss. You would expect them to play like that. They disrupted us a little offensively.”

“A little” is an understatement.

Pitt saw its 10-game winning streak snapped in by far its worst outing of the season. The Panthers came into the game averaging more than 85 points a game but were held to a season-low and the program’s lowest total since a 62-39 loss to Rutgers on Jan. 11, 2012. It was the Panthers’ fifth-fewest points since 1954-55.

To illustrate just how gnarly it was for the Panthers: the football team scored 42 points in the first half of its 45-34 win over Louisville in November, one more than the basketball team could manage all game Thursday.

“I can’t think of anything we did well, so we are disappointed by our performance,” Pitt coach Jamie Dixon said. “Obviously the numbers don’t add up for us.”

Chinanu Onuaku had 18 points and 10 rebounds, the fourth consecutive double-double for Louisville’s sophomore center.

Damion Lee scored 18 points for the Cardinals (14-3, 3-1 Atlantic Coast Conference).

“If Nanu wants to, he could be the most dominant player in the ACC,” Lewis said. “And he wants to. I’m starting to see that more and more. He demands the ball. He wants the ball inside and he makes great decisions with the ball. I don’t think anybody can handle him one-on-one.”

Onuaku has struggled with foul trouble at times this season. He was limited to just 20 minutes in Louisville’s 66-62 loss at Clemson on Sunday but had 14 points and 10 rebounds.

“Right now, if he plays 33 minutes we’re going to be tough to beat,” Louisville coach Rick Pitino said.

The game resembled a Big East brawl of a bygone era.

Louisville led 20-17 at halftime, the lowest halftime total for both teams this season. Both teams were 1-of-11 (9 percent) from 3-point range. Louisville had a 34-20 advantage on points in the paint.

Pitt entered the game leading the nation in free throw percentage but shot just 12 of 20 (60 percent) from the line.

Onuaku carried the Cardinals in a myriad of ways — hitting jumpers from the baseline and top of the key to go with dunks.