NEW YORK — No Manning. No Brady, for the first four games. No clear-cut favorite in the AFC.

With the regular season about to kick off, it’s anybody’s guess who’ll be the conference’s representative at the Super Bowl in Houston in February.

The defending champion Denver Broncos will try to become the first team to repeat since New England in 2004-05. But they won’t have the retired Peyton Manning leading the way. Or even Brock Osweiler, who bolted from the Broncos and headed to Houston. Instead, Gary Kubiak and the Broncos have been trying to sort out a quarterback mix that includes veteran Mark Sanchez, 2015 seventh-rounder Trevor Siemian and rookie Paxton Lynch, the team’s first-rounder this year.

“You want to see the other guy succeed, you want to see the team succeed,” Sanchez said. “So, whatever it takes to win, that’s what we’ll try to do.”

While their quarterback situation might be a big question mark, the Broncos know they’ve got one of the league’s best defenses back, especially with the return of Super Bowl MVP Von Miller.

“If we’re like last year, our team didn’t worry about the other side of the ball,” defensive coordinator Wade Phillips said. “They worried about how well they played. That’s what we want to do. We have to outplay the other team’s defense. If they hold our team to not much, then we hold them to less. That’s the way we play the game.”

New England knows who its quarterback will be at the start of the season. Jimmy Garoppolo steps in for the suspended Tom Brady, who’ll have to sit four games as a result of his role in the “Deflategate” scandal.

That might make the Patriots’ stranglehold on the AFC East appear looser after winning the division the last seven years. Well, not so fast on writing off Bill Belichick’s bunch.

“Belichick is Belichick,” Buffalo safety Corey Graham said. “He’s one of the best, so when it’s all said and done, you know he’s going to get those guys prepared and make sure they’re ready to go.”