CHICAGO — The widely used diabetes pill Actos appears to lower a patient's chances of death, heart attack or stroke, unlike its beleaguered chief rival Avandia, a new analysis shows.

However, it also carries an increased risk of nonfatal heart failure, the analysis showed, confirming earlier studies. Heart failure is also a side effect with Avandia. Such problems led one diabetes expert to recommend that both drugs be considered second choices behind older, cheaper pills.

Heart failure "is a significant side effect," said Dr. Alvin Powers, director of Vanderbilt University's diabetes center. "No one would say that you should be on these drugs to prolong your life." He was not involved in the research.

Older drugs including Metformin are available in generic form and can cost less than 20 cents a day — 10 times less than Avandia and Actos. However, the older drugs can stop working and doctors may try newer pills instead of having patients resort to insulin injections.

When the older drugs lose effectiveness, Actos "is a drug that clearly I think is preferable," said Dr. A. Michael Lincoff, who co-authored the Actos study with Cleveland Clinic colleague, Dr. Steven Nissen.

Their research was paid for with a $25,000 grant from Takeda Global Research & Development, a Deerfield, Ill., division of Actos' maker, Takeda Pharmaceutical Co. of Osaka, Japan. Takeda had no role in designing their analysis.

A third author, Cleveland Clinic researcher Stephen Nicholls, has received consulting fees from drug companies, including Takeda. Lincoff and Nissen also reported getting research funds from other diabetes drug makers and they have consulted for several drug companies. They said any fees are donated to charity.

The review, appearing in Wednesday's Journal of the American Medical Association, is the biggest to date on Actos. It pools results of 19 rigorous studies involving more than 16,000 people. Compared with patients taking other diabetes drugs or none, Actos patients had an 18 percent reduced risk of death, heart attack or stroke.

The findings are important because heart attacks are a leading cause of death in diabetics, the authors said.

The same researchers wrote an analysis earlier this year linking Avandia with increased heart attack risks, and a drug advisory panel is recommending stronger warnings on that drug's packaging. The FDA has not acted on that recommendation.

The agency is requiring label warnings of the heart failure risks for both Avandia and Actos.

Takeda's Dr. Robert Spanheimer said the Actos analysis adds "scientific validity" to previous data on the company's drug.