Indianapolis fans treated Peyton Manning like a returning hero before he led the Broncos against their team.

Then the Colts treated Manning unkindly Sunday night, handing Denver (6-1) its first loss of the season, 39-33.

As a sign in the crowd read: “No Longer Peyton’s Place.”

“I had some advice from some people to really appreciate that moment,” Manning said. “I enjoyed coming back here.

“This is a game we need to learn from. We had four turnovers and somehow had a chance to win,” added Manning, who finished 29 of 49 for 386 yards with three TDs and one interception. He was sacked four times. “Kind of relieved this game is over. If there is a next time, it might be somewhat easier. It was an emotional week and it can be draining.”

Andrew Luck threw for three touchdowns and ran for another. And the Colts (5-2) took advantage of Manning’s and Denver’s uncharacteristic mistakes.

“I never looked at it as the guy who replaced Peyton,” Luck said after beating Manning. “I just look at it as a chance to play football for a great team.

“It’s a good one against one of the better teams in the league.”

At least Manning got out of Indy healthy. It was not a good day for three other quarterbacks, all of whom were injured in defeats. Sam Bradford damaged his left knee in a 30-15 loss at Carolina, Jay Cutler left Chicago’s 45-41 loss at Washington with a groin problem, and Nick Foles suffered a head injury in a 17-3 defeat against Dallas.

Panthers 30, Rams 15

Cam Newton is finding his stride for Carolina (3-3). He completed 15 of 17 passes for 204 yards and a touchdown in a heated game.

The Rams (3-4) lost their cool with several personal foul penalties — and then lost Bradford to a left knee injury late in the fourth quarter. Bradford was running toward the sideline when he was pushed out of bounds by safety Mike Mitchell and came up holding his left knee. He was carted to the locker room.

Redskins 45, Bears 41

Visiting Chicago (4-3) left with its third loss in four games. Roy Helu’s third touchdown, a 3-yard run with 45 seconds to play, lifted the Redskins (2-4).

Robert Griffin III completed 18 of 29 passes for 298 yards with two touchdowns. Griffin also ran 11 times for a season-high 84 yards against a defense depleted by injuries, but the breakout performance came from rookie tight end Jordan Reed, who caught nine passes for 134 yards and one touchdown.

Josh McCown, playing in a regular-season game for the first time since 2011, completed 14 of 20 passes for 204 yards with one touchdown for Chicago. Matt Forte rushed for three touchdowns.

Cowboys 17, Eagles 3

The Eagles (3-4) have lost a franchise-worst nine straight games at home. Their last win at Lincoln Financial Field was over the New York Giants on Sept. 30, 2012; they play the Giants next Sunday.

Tony Romo threw for 317 yards and one touchdown to offset a generally mediocre offensive performance for much of the game. Dallas (4-3) leads the NFC East.

A Cowboys defensive line missing three of its projected starters pressured and harassed Foles before sending him to the sideline with a head injury on the last play of the third quarter.

Chiefs 17, Titans 16

The Chiefs, 2-14 last year, are the NFL’s only remaining unbeaten.

Jamaal Charles ran for 86 yards and a touchdown, Alex Smith also ran for a score and the scrappy Chiefs held off the banged-up Texans.

Tamba Hali had 2 1-2 sacks and forced a clinching turnover when he stripped QB Case Keenum in the final minutes. Derrick Johnson recovered the fumble for host Kansas City (7-0).

“It’s confidence,” said Hali. “Guys believe in what we’re doing. They believe in one another, and that goes a long way.”

Keenum, making his first NFL start in place of the injured Matt Schaub, threw for 271 yards and a touchdown for the Texans (2-5). Houston running back Arian Foster left in the first quarter with a hamstring injury and did not return.

Jets 30, Patriots 27

The host Jets (4-3) snapped a six-game regular-season slide against New England (5-2) when Nick Folk kicked a 42-yard field goal with 5:07 left in overtime. Folk got a second chance after he missed a 56-yarder moments earlier. But Chris Jones was called for unsportsmanlike conduct for pushing a teammate forward to try to block the kick, a new NFL rule.

Geno Smith threw a touchdown pass and ran for another score.

New England tied it at 27 with 16 seconds left in regulation on Stephen Gostkowski’s 44-yard field goal.

Bengals 27, Lions 24

At Detroit, Mike Nugent’s 54-yard field goal as the game ended lifted the AFC North-leading Bengals (5-2). They won the same way last week when he made an overtime kick to give Cincinnati a win after it blew a 14-point, fourth-quarter lead at Buffalo

The Lions (4-3) looked like they did enough to send the game to OT, but rookie Sam Martin shanked a punt just 28 yards to midfield in the final minute. Andy Dalton, who threw three touchdown passes, took advantage with two short passes to set up the winning field goal.

49ers 31, Titans 17

At Nashville, Colin Kaepernick threw for 199 yards and ran for 68 and a touchdown. The 49ers (5-2) won their fourth straight before heading to London for a game with winless Jacksonville by jumping to a 17-0 halftime lead. Frank Gore also ran for a pair of 1-yard TDs, Tramaine Brock intercepted a pass, Justin Smith had two of the 49ers’ three sacks, and Kassim Osgood recovered a muffed punt for a TD.

Chargers 24, Jaguars 6

At Jacksonville, the Jaguars fell to 0-7 as Philip Rivers threw for 285 yards and a touchdown, and Ryan Mathews ran for 110 yards and a score.

Falcons 31, Bucs 23

At Atlanta, Matt Ryan threw for 273 yards and three touchdowns, including two to Jacquizz Rodgers, and the Falcons snapped their three-game losing streak.

Harry Douglas had seven receptions for a career-best 149 yards, including a 37-yard touchdown catch, for the Falcons (2-4).

Packers 31, Browns 13

At Green Bay, the Packers (4-2) took the NFC North leads with their third straight win, built on a balanced offense. Aaron Rodgers passed for 260 yards and three touchdowns, and Eddie Lacy ran for another score and gained 82 yards.

The defense took care of the rest against struggling quarterback Brandon Weeden, who was 17 for 42 for 149 yards. Tight end Jordan Cameron caught a 2-yard touchdown pass in the fourth quarter for Cleveland (3-4).

Bills 23, Dolphins 21

At Miami, Mario Williams forced a fumble when he sacked Ryan Tannehill with less than three minutes left, setting up the winning field goal by former Dolphins kicker Dan Carpenter. Miami released Carpenter in August after five seasons.