OKLAHOMA CITY — From the opening tip of the season, there was only one question in women’s college basketball: How do you stop Brittney Griner?

Louisville found the answer Sunday night, pulling off one of the biggest upsets in the history of the tournament.

Considered a lock for the Final Four — and prohibitive favorites to win a second straight championship — Griner and her Lady Bears got bounced 82-81 by fifth-seeded Louisville in an NCAA regional semifinal.

“I’m just sad,” Griner said. “I didn’t do what I needed to do to get my team to the Elite Eight and just disappointment in myself.”

Baylor (34-2) had won 32 straight games and 74 of 75 behind Griner, among the greatest players ever in her sport. But the 6-foot-8 star didn’t make a basket until the second half, then committed a foul with 2.6 seconds left that gave Louisville a chance to win.

Monique Reid made those two foul shots, rescuing the Cardinals (27-8) after they squandered a 17-point lead in the last 7½ minutes.

Tennessee 74, Oklahoma 59

OKLAHOMA CITY — Kamiko Williams scored 15 points, Cierre Burdick had 13 and second-seeded Tennessee routed Oklahoma in the regional semifinals of the NCAA women’s tournament.

The Lady Vols (27-7) opened a 20-point lead in the first half and never let Oklahoma make a comeback, improving to 26-5 in regional semifinals.

Notre Dame 93, Kansas 63

NORFOLK, Va. — Skylar Diggins scored 22 of her 27 points by halftime and became the school’s career scoring leader, helping the top-seeded Fighting Irish to a victory against Kansas in the semifinals of the Norfolk Regional.

And Diggins made it look easy, adding nine assists and three steals, and scoring nine straight during a 16-2 first-half run that put the Irish (34-1) ahead to stay.

The victory was the 29th in a row for Notre Dame.

Duke 53, Nebraska 45

NORFOLK, Va. — Tricia Liston scored 17 points and Duke shook off a slow start to beat Nebraska in the semifinals of the Norfolk Regional of the women’s NCAA tournament.

Alexis Jones added 14 points for the Blue Devils (33-2), who also struggled last weekend at home.