Derwin Kitchen scored 22 points and unranked Florida State pulled off its latest upset of No. 1 Duke, snapping the Blue Devils’ 25-game winning streak with a 66-61 victory Wednesday night at Tallahassee, Fla.

Chris Singleton added 18 points for Florida State (12-5, 2-1 Atlantic Coast Conference), which made five free throws in the final 33 seconds to hold off the defending national champions. It was the third time since 2002 that the Seminoles beat a top-ranked Duke team at home.

The Blue Devils (15-1, 2-1) hadn’t lost since a 79-72 setback on March 3, 2010, at Maryland. From there, they went on to win the ACC and NCAA tournaments for their fourth national title.

The 25-game winning streak was the second-longest in Duke history.

Kyle Singler scored 20 points and Nolan Smith had 19 for the Blue Devils, who missed their first 10 3-point attempts and shot 31.1 percent overall, ending their run at a perfect season.

No. 2 Ohio State 68, Michigan 64At Ann Arbor, Mich., William Buford scored 19 points and the Buckeyes went on a 12-0 run in the second half before holding off the Wolverines.

No. 3 Kansas 84, Iowa State 79At Ames, Iowa, Marcus Morris set career highs with 33 points and 13 rebounds, Markieff Morris added 17 points and the Jayhawks held off the Cyclones to win its 20th straight conference opener.

No. 4 Syracuse 76, St. John’s 59At New York, Kris Joseph scored 18 points and the Orange remained undefeated by beating the Red Storm at Madison Square Garden.The Orange (17-0, 4-0 Big East) are off to the second-best start in school history.The win was the 1,800th in school history, fifth on the all-time list in Division I and 846 of them have been under coach Jim Boeheim.

No. 7 Villanova 88, No. 18 Louisville 74At Philadelphia, Corey Stokes scored 23 points and Mouphtaou Yarou had 18 points and 11 rebounds to lead the Wildcats over the Cardinals for their 10th straight win.

No. 25 Cincinnati 74, South Florida 66At Cincinnati, redshirt freshman Sean Kilpatrick scored 18 points, giving the Bearcats some spark as they rebounded from their first loss of the season.