Pittsburgh Pirates pitcher Paul Skenes throws during the first inning Friday against the Chicago Cubs in Chicago. Associated Press

CHICAGO — Isiah Kiner-Falefa hit a sacrifice fly in the 10th inning to help the Pittsburgh Pirates beat the Chicago Cubs 2-1 Friday.

The Pirates loaded the bases in the 10th on Ke’Bryan Hayes' infield single and a walk to Henry Davis. Kiner-Falefa then drove in Adam Frazier with a fly ball to left off Drew Pomeranz (2-1).

Kiner-Falefa also threw out Ian Happ when he attempted to score from first on Kyle Tucker's two-out double in the fifth inning.

Dennis Santana (2-1) got five outs for the win, and David Bednar worked a perfect 10th for his 10th save.

Pirates ace Paul Skenes struck out five in five scoreless innings. He allowed four hits and walked two while throwing 95 pitches, 60 for strikes.

Skenes was matched by Cade Horton, who permitted three hits in 5 2/3 shutout innings for the NL Central leaders.

Pittsburgh Pirates pitcher Paul Skenes (30) throws during the first inning of a baseball game against the Chicago Cubs, Friday, June 13, 2025, in Chicago. (AP Photo/David Banks)