PHILADELPHIA — Tom Brady threw two touchdown passes, Leonard Fournette ran for two scores and the Tampa Bay Buccaneers beat the Philadelphia Eagles 28-22 on Thursday night.

The defending Super Bowl champion Buccaneers (5-1) lost another cornerback when three-time All-Pro Richard Sherman left in the first quarter with a hamstring injury but their depleted defense held on after Jalen Hurts rallied the Eagles from a 28-7 deficit.

Playing with an injured thumb, Brady came out firing. The 44-year-old, seven-time Super Bowl champion tossed TD passes on Tampa Bay’s first two drives while going 11 for 12 for 121 yards.

His best play came after Hurts’ second TD run and a 2-point conversion pulled Philadelphia within six points with 3:05 left in the fourth quarter.

Facing a third-and-7 from Philadelphia’s 45, Brady rolled away from pressure and threw a perfect pass to Antonio Brown for a 27-yard gain to extend the drive and the Bucs ran out the clock.

The Eagles (2-4) are winless in three home games under rookie coach Nick Sirianni. They heard boos at halftime but fought back to make it close.