PITTSBURGH — Justin Steele breezed through seven shutout innings and the Chicago Cubs scored six runs in the second inning Thursday night, beating Pittsburgh 9-0 and sending the Pirates to their 100th loss of the season.

Steele (4-4) struck out seven and gave up four hits on 76 pitches. The rookie left-hander, who hadn't gone more than five innings in eight major league starts, bounced back after allowing six runs and seven hits against the St. Louis Cardinals on Sept. 24.

Pittsburgh joined Texas, Baltimore and Arizona, giving MLB four 100-loss teams for the third time, after 2002 and 2019. The Pirates hadn't lost 100 games since 2010, when they finished 57-105.

Sergio Alcántara drove in three runs, two coming on a homer to right off Miguel Yajure (0-2) that gave Chicago a 3-0 lead in the six-run second. Steele helped his own cause with a single and scored on a groundout by Frank Schwindel, Rafael Ortega took home on a double steal, Willson Contreras had an RBI double and Matt Duffy made it 7-0 with a single.

The Cubs took the final two of the three-game series following a seven-game losing streak.

Yajure lasted just two innings, allowing seven runs on seven hits. He surrendered seven combined runs across 13 innings in three previous appearances (two starts) for the Pirates this season.

Chicago jumped on Yajure early, with Ortega driving the first pitch of the game 388 feet over the right-field wall for his 11th home run of the season.

David Bote and Alcántara had back-to-back RBI singles off reliever Tanner Anderson, extending the lead to nine runs in the fifth.

Cubs: C Erick Castillo was selected from Triple-A Iowa.Pirates: RHP Roansy Contreras was optioned to Triple-A Indianapolis. He allowed three hits with four strikeouts in three innings of his major league debut Wednesday. … Anderson was selected from Indianapolis. He gave up two runs on two hits in five innings of relief, his first major league appearance since July 4, 2019, with Oakland.

Cubs: C Austin Romine was placed on the injured list.Pirates: LHP Dillon Peters (lower back strain) was transferred from the 10-day IL to the 60-day IL.