PITTSBURGH — A Pittsburgh-area medical system is re-opening its organ transplant program, six days after closing it because of concerns mold contributed to the deaths of three transplant patients who had fungal infections.

The University of Pittsburgh Medical Center reopened the program Sunday after its procedures and treatments were reviewed by the Pennsylvania Department of Health and the U.S. Centers for Disease Control and Prevention.

The Department of Health says UPMC must submit a plan to improve infection and mold control. It didn't say whether mold caused the deaths or whether investigators had found the source of the mold.

UPMC has said a fourth patient was fighting a fungal infection.

NEW YORK — Alcoa will split into two independent companies, separating its bauxite, aluminum and casting operations from its engineering, transportation and global rolled products businesses.The metals maker has been dealing with a downturn in its smelting business because of lower aluminum prices.The split will create one company focusing on upstream products, including aluminum. The other company will focus on engineered products, which includes the automotive and aerospace segments.The aluminum and upstream products company will retain the Alcoa name.

ANCHORAGE, Alaska — Royal Dutch Shell will cease exploration in Arctic waters off Alaska's coast following disappointing results from an exploratory well backed by billions in investment and years of work.The announcement was a huge blow to Shell, which was counting on offshore drilling in Alaska to help it drive future revenue. However, environmentalists, had tried repeatedly to block the project and welcomed the news.Shell has spent upward of $7 billion on Arctic offshore exploration, including $2.1 billion in 2008 for leases in the Chukchi Sea off Alaska's northwest coast, where an exploratory well about 80 miles off shore drilled to 6,800 feet but yielded disappointing results.