NEW YORK — Melissa McCarthy left the guys of “Entourage” in the dust, landing her first No. 1 box-office debut as a leading lady with an estimated $30 million weekend for the espionage comedy “Spy.”

The result added to the string of successes for McCarthy and writer-director Paul Feig, who first united on the 2011 hit “Bridesmaids.” While “Spy” fell short of the $39.1 million debut of their 2013 comedy “The Heat,” with Sandra Bullock, and came in a tad lower than some predicted, it was good enough to win a weekend lacking blockbuster punch but crowded with action, horror and the resurrected HBO series.

“It sets the table for a fantastic long run,” said Chris Aronson, head of distribution for 20th Century Fox.

Last week’s top film, “San Andreas,” the disaster movie starring Dwayne “The Rock” Johnson, slid to second place with $26.4 million. “Insidious: Chapter 3” opened with an estimated $23 million.

But HBO’s “Entourage,” made for about $30 million, failed to compete with those releases. The film, released about four years after the series concluded, made $10.4 million over the weekend and has brought in a five-day total of $17.8 million since opening Wednesday.

Dan Fellman, head of distribution for Warner Bros., said advance tracking for the film had been soft and that comparisons to “Sex and the City” weren’t accurate. That 2008 release opened with $57 million.