LONDON — After taking a tiebreaker by the score of 19-17 on the way to reaching Wimbledon’s third round for the first time, John Isner put it quite succinctly: “I’m no stranger to matches like this.”

The man who is best known for winning the longest tennis match in history did what he does best, serve well, and beat 62nd-ranked Jarkko Nieminen of Finland 7-6 (17), 7-6 (3), 7-5 with the help of 32 aces Thursday.

“That tiebreaker was something else,” said the ninth-seeded Isner, the only American man remaining of the 10 who were in the field. “Fortunately, I won.”

Only one men’s singles tiebreaker at Wimbledon contained more points than the 36 played by Isner and Nieminen: Bjorn Borg won a tiebreaker 20-18 in 1973.

Isner fought off five set points for Nieminen in that tiebreaker.

By winning a pair of tiebreakers Thursday, Isner improved to 24-12 in the set-deciding format this season.

“For whatever reason, when I’m that situation, I always have a lot of adrenaline, and I’m always serving my best,” said Isner, who beat Nicolas Mahut 70-68 in the fifth set of an 11-hour, 5-minute match spread over three days in Wimbledon’s opening round in 2010.

The three other American men in action Thursday lost. Sam Querrey was beaten 14-12 in the fifth set by No. 14 Jo-Wilfried Tsonga of France in a match that was halted because of fading light at 9-all Wednesday night.

Jack Sock went out in straight sets against No. 8 Milos Raonic of Canada, and Denis Kudla did the same against No. 10 Kei Nishikori of Japan.

Led by five-time champion and top-seeded Serena Williams and her sister Venus, also a five-time titlist at Wimbledon, the U.S. women are faring better, with five already into the third round.

Two won their second-round matches Thursday: Madison Keys, who lives in Florida, beat 31st-seeded Klara Koukalova of the Czech Republic 7-5, 6-7 (3), 6-2, and Alison Riske, who is based in Georgia, eliminated Camila Giorgi of Italy 7-5, 6-2.