ORCHARD PARK, N.Y. — Buffalo Bills rookie quarterback E.J. Manuel has a sprained lateral collateral ligament in his right knee that will not require surgery but will sideline him at least two weeks and potentially longer, coach Doug Marrone said Friday.

Manuel was injured in the third quarter of Buffalo’s 37-24 loss at Cleveland on Thursday, when he was hit by Browns safety Tashaun Gipson at the end of a 14-yard run.

Marrone said it is too early to determine an exact timetable for Manuel’s return.

Rookie Jeff Tuel came in for Manuel but was ineffective, completing 8 of 20 passes for 80 yards.

Marrone said the Bills (2-3) will look into acquiring another quarterback and did not rule out the possibility of that player starting Buffalo’s next game Oct. 13 at Cincinnati (2-2).