ATLANTA — After a season of uncertainty, there’s a clear favorite heading to the Final Four.

The Louisville Cardinals.

While the other No. 1s have fallen by the wayside, the top overall seed romped to the Georgia Dome with four dominant wins in the NCAA tournament. And, if the Cardinals need any extra motivation, they’ve got it.

Sophomore guard Kevin Ware, who played his high school ball in the Atlanta suburbs, sustained a gruesome injury in Sunday’s regional final against Duke. Before he headed off to surgery, he courageously urged his teammates to finish the job.

Now, they would like nothing more than to win it all for Ware.

“We talked about it every timeout, `Get Kevin home,”’ coach Rick Pitino said.

Next stop, the A-T-L, where three rather unlikely teams will be looking to knock off the mighty Cardinals.

First up, the surprising Shockers from Wichita State in the semifinals Saturday. The No. 9 seed has already pulled off two major upsets, but this would be the biggest stunner yet.

If Louisville makes it through to next Monday night’s title game, the opponent would be either Michigan, sporting a new group of Fab Wolverines, or Syracuse, which comes at you with the stingiest zone defense in college basketball. The two No. 4 seeds will meet in the other semifinal game.

All are underdogs to the Cardinals, who are winning by an average of nearly 22 points a game in the tournament.

“I thought we had a chance there, and then boom,” said Duke coach Mike Krzyzewski, who watched Louisville pull away for an 85-63 victory in the Midwest Regional final. “That’s what they do to teams. They can boom you.”

In the other game Sunday, Michigan captured the South Regional with a 79-59 rout of Florida, leading from the opening tip. A day earlier, Syracuse shut down Marquette 55-39 to win the East Regional, while Wichita State punched its Final Four ticket with a 70-66 upset of Ohio State out West.

In the final year of the Big East before it splits into two new conferences, Louisville and Syracuse provided a fitting send-off to a league that quickly became a basketball powerhouse after it was founded in 1979.

Before it goes, this version of the Big East has a shot at one more national title.

With two teams, no less.

The Cardinals — who, like Syracuse, are moving to the Atlantic Coast Conference — shook off the incredible shock of Ware’s injury with about 6½ minutes to go before halftime and blew out the second-seeded Blue Devils. The sophomore snapped his lower right leg after coming down awkwardly while defending a 3-point shot. The injury occurred right in front of the Louisville bench, where the players gasped and turned away quickly at the sight of Ware’s dangling leg, which was broken in two places.

Russ Smith collapsed onto the floor, along with several players, and was crying as doctors attended to Ware. While Ware was loaded onto a stretcher, the Cardinals gathered at midcourt until Pitino called them over, saying the injured player wanted to talk to them before he left.

“All he kept saying — and remember, the bone is 6 inches out of his leg — all he’s yelling is, `Win the game! Win the game!”’ Pitino said. “I’ve never seen that in my life. We’re all distraught and all he’s saying is, `Win the game.’ Kevin is a special young man.”

This is a special team. Smith scored 23 points. Gorgui Dieng had 14 points, 11 rebounds and four blocks.

The Cardinals (33-5) simply refused to lose, breaking open a game that was tied at 42. They dove on the floor for loose balls. They pounded the boards ferociously. They contested every shot and swarmed around the Blue Devils like they had an extra player on the court.

In a sense, they did, as Pitino reminded them during every timeout.

“This is a gritty bunch,” the coach said. “From the beginning of the year to now, they’ve not had a bad game. I’m really proud of these guys.”