Meet “Little Fockers,” the latest in Robert De Niro and Ben Stiller’s comedy franchise. Grit your teeth through the fairly short though agonizing duration of its stay.

“Meet the Parents” from 2000 was a tolerable trifle and 2004’s “Meet the Fockers” was a bloated bore. But “Little Fockers” is tasteless trash, filled with abysmally unfunny gags involving vomit, enemas, erectile dysfunction and the like as De Niro’s Byrnes clan and Stiller’s Focker family stumble through another mindless reunion.

The only positive thing De Niro, Stiller and such co-stars as Barbra Streisand, Dustin Hoffman, Jessica Alba and Owen Wilson honestly could say about “Little Fockers” is that they were paid well.

Jay Roach, who directed the first two movies, only produces this time, with Paul Weitz filling in as director on “Little Fockers.”

A string of dumb episodes, “Little Fockers” strains to find new reasons for De Niro’s father-in-law from hell Jack Byrnes to revive his suspicions about Stiller’s Greg Focker, the male nurse his darling daughter Pam (Teri Polo) has chosen for a mate.

It all goes down as Jack and his wife (Blythe Danner) visit Greg and Pam for the birthday bash of the couple’s twins. Ex-CIA agent Jack resumes his surveillance of Greg, who has an innocent flirtation with a gorgeous pharmaceutical rep (Alba) peddling Sustengo, a new drug to treat impotence.

Really. This is what the filmmakers expect you to pay to see.

Wilson is back as Pam’s old flame, doing the same passive-aggressive pining and whining he did in the first two movies. Streisand and Hoffman return as Greg’s touchy-feely parents, whose sexual frankness again leaves the upright Jack unsettled.

Laura Dern joins the cast in a pointless role as head of a school that Greg and Pam are considering for their kids.

A confrontation between De Niro and Harvey Keitel as Greg’s housing contractor could have been a real hoot given the long history between the two actors, pals since their early days in Martin Scorsese films. But it’s just stiff, awkward and humorless, like the rest of the movie.