LOUISVILLE, Ky. — Another game, another injured quarterback, and yet another steppingstone for surprising Cincinnati.

Dustin Grutza came off the bench in the fourth quarter to lead the game-clinching drive as the 22nd-ranked Bearcats surged past reeling Louisville 28-20 on Friday to stake their claim as the team to beat in a crowded Big East.

The victory gives Cincinnati (8-2, 4-1) a half-game lead over idle WVU and No. 21 Pitt in the conference football title race. Cincinnati beat the Mountaineers last week and hosts the Panthers Nov. 22.

The Bearcats won the way they have all season, with another hero hobbling in off the bench and just enough big plays on defense to make it hold up.

Grutza, who began the season as the starter before breaking his leg in a loss to Oklahoma in September, guided a 72-yard touchdown drive after starter Tony Pike went out with an injury to give the Bearcats their first victory over the Cardinals (5-5, 1-4) in six years.

"It's kind of a magical situation for those who have followed our quarterback trials and tribulations," said coach Brian Kelly.

Figures.

It's been somewhat of a magical season for the Bearcats, who celebrated by racing to the end zone and grabbing the Keg of Nails — the rivalry trophy that's tormented them for years.

"I think we can all say the rivalry is back," Kelly said. "There was a lot of emotion out on the field in this game."

Maybe, but the Bearcats also know the win only raises the stakes for next week's showdown with Pitt.

"The next game is the biggest game," said cornerback Mike Mickens, who added to his school record with the 14th interception of his career. "Beating Pitt is the next task."

Dominick Goodman caught nine passes for 134 yards and a touchdown as the Bearcats beat Louisville for the first time since 2002.

"It means a lot for this program to come in here and win the Keg of Nails," Goodman said. "We'd like to keep it for a long, long time."