The Titans were beaten for the first time. The Colts were headed for a 1-3 start.

Not so fast.

Thanks to a stunning rally, Tennessee edged Baltimore 13-10 in a brutally physical and penalty-filled game Sunday. Then Indianapolis, helped greatly by gifts from Houston, topped the Titans' comeback with an even more improbably turnaround for a 31-27 victory.

"The idea today was to get a little swagger back," Colts star Peyton Manning said after throwing for two touchdowns in a 2:10 span late in the fourth quarter. "I was proud of the guys for never giving up and fighting 'til the end."

The Colts scored 21 points in that 2:10 — two touchdowns thanks to fumbles by Texans quarterback Sage Rosenfels — then intercepted Rosenfels' last-ditch comeback attempt.

Manning connected with Reggie Wayne on a 5-yarder with 1:54 remaining for the decisive points. Linebacker Gary Brackett returned a fumble by quarterback Rosenfels 68 yards for a score in between Manning's TD throws.

"For one play I made a really stupid mistake and that started the downward spiral," Rosenfels said. "I feel like I let those guys down."

Rookie Tom Santi caught the other late score, a 7-yarder to bring the Colts (2-2) to 27-17 with 4:04 to go. It was his first NFL touchdown.

Tennessee now is the AFC's lone undefeated team thanks to some late magic from Kerry Collins and a hard-hitting defense.

Kerry Collins threw an 11-yard touchdown pass to Alge Crumpler with 1:56 left. The Titans (5-0) trailed 10-6 before Collins directed an 11-play, 80-yard scoring drive. The march was aided by a penalty against Baltimore's Terrell Suggs, who was flagged for a blow to Collins' helmet — although it appeared to be incidental contact.

Baltimore rookie Joe Flacco was then intercepted by Nick Harper, assuring the Ravens (2-2) a second straight defeat.

"It wasn't always pretty today. It wasn't my best game," Collins said. "But at the end of the game we found a way to win."

Backup Rosenfels, playing for the ill Matt Schaub, had the winless Texans (0-4) ahead by 17 points before the late collapse.

At Baltimore, the game was marred by several skirmishes, most of which resulted in personal foul penalties. Tennessee was penalized 10 times for 78 yards, including two 15-yard infractions that fueled both Baltimore's scoring drives.

At Glendale, Ariz., Buffalo's second-year quarterback Trent Edwards went down with a concussion on a fierce hit from safety Adrian Wilson on the third play of the game.

At Denver, Jay Cutler guided a patient Denver offense over the Buccaneers (3-2). Brandon Stokley hauled in Cutler's pass in the right flat and followed Brandon Marshall's big block for a 10-yard touchdown, and Matt Prater kicked three field goals for Denver (4-1).

At Irving, Texas, Dallas (4-1) led 17-0 after only three drives, but ended up getting big plays from Terrell Owens, Tank Johnson and Keith Davis to stave off the bumbling Bengals (0-5).

At San Francisco, Kevin Faulk rushed for two scores, Matt Cassel had 259 yards passing and the Patriots won in San Francisco (2-3) for the first time in franchise history.Randy Moss had five catches for 111 yards for the Patriots (3-1).

At Miami, Ronnie Brown scored the decisive touchdown from the single-wing formation the Dolphins revived two weeks ago. Miami (2-2) held LaDainian Tomlinson to 35 yards on 12 carries. The Chargers fell to 2-3.

East Rutherford, N.J., In a nearly flawless performance, Eli Manning threw two touchdowns, Brandon Jacobs ran for two more and the unbeaten Giants (4-0) scored on their first five possessions.

At Green Bay, Wis., Atlanta rookie quarterback Matt Ryan turned in another sharp performance, completing 16 of 26 passes for 194 yards, two touchdowns and an interception.

At Philadelphia, Clinton Portis ran for 145 yards and one touchdown and wide receiver Antwaan Randle El threw a TD pass for Washington (4-1).

Charlotte, N.C., DeAngelo Williams had 123 yards rushing and scored three touchdowns, and the Panthers (4-1) handed the Chiefs their first shutout in nearly six years.

At Detroit, Kyle Orton set career highs in yards passing, completions and quarterback rating while throwing two touchdowns. He was 24-of-34 for 334 yards.