SAN FRANCISCO — Talk show host Tom Snyder, whose smoke-filled interviews and robust laughter were a staple of late night television, has died after a struggle with leukemia. He was 71.

Snyder died Sunday in San Francisco from complications associated with leukemia, his longtime producer and friend Mike Horowicz revealed today.

Known for his improvised, casual style, Snyder conducted a number of memorable interviews as host of NBC's "The Tomorrow Show." Among his guests were John Lennon, Charles Manson and Johnny Rotten of the Sex Pistols.

Snyder began his career as a radio reporter in Milwaukee in the 1960s, then moved into local television news. He anchored newscasts in Philadelphia and Los Angeles before moving to late night.

"He loved the broadcast business," said Marciarose Shestack, who co-anchored a noontime newscast with Snyder at KYW-TV in Philadelphia in the 1960s. "He was very surprising and very irreverent and not at all a typical newscaster."

In 1972, Snyder left news to host "The Tomorrow Show," which followed "The Tonight Show" with Johnny Carson.

His catch phrase for the show was: "Fire up a colortini, sit back, relax, and watch the pictures, now, as they fly through the air." Snyder smoked throughout his show, the cigarette cloud swirling around him during interviews.

He gained more fame when Dan Aykroyd lampooned him in the early days of Saturday Night Live.

In 1995, he returned to late night television as the host of "The Late Late Show with Tom Snyder" on CBS. The program followed David Letterman's "Late Show" until 1998, when Snyder was replaced by Craig Kilborn.