LOS ANGELES — How can you top being a killing machine from the future? Stepping into the shoes of an indestructible superhero isn't half bad.

Kristanna Loken, best known for playing the T-X in "Terminator: Rise of the Machines," will star as the Sci-Fi Channel's action heroine "Painkiller Jane," which is slated for 22 one-hour episodes.

In the drama based on the Jimmy Palmiotti and Joe Quesada comic book, Loken stars as DEA agent Jane Vasko who's in a covert operation to hunt for "Neuros," genetically enhanced people with superhuman mental powers. Early on, however, she learns that she also has extraordinary abilities that allow her to heal and regenerate fully from any injuries, making her pretty much invulnerable. Of course, she still feels the pain, so it's not all gravy.

As she continues her pursuit of the Neuros, they just might be the answer to why her body has undergone this particular transformation.

Loken will pull double duty as a co-executive producer on "Painkiller Jane" along with showrunner Gil Grant ("24," "NCIS").

Insight Film Studios, in association with Starz Media and Kick-start Comic Arts Studio, will produce the project, which begins production in Vancouver in November. Sci-Fi will premiere the series in Spring 2007, followed by a domestic broadcast weekly syndication window in the fall.

Loken's other film credits include "BloodRayne" and the upcoming Uwe Boll film, "In the Name of the King: A Dungeon Siege Tale."

On TV, she'll guest star on Showtime's "The L Word" this coming season. She's also appeared on "Sliders," "Mortal Kombat: Conquest" and starred in Sci-Fi's miniseries "Dark Kingdom."