LOS ANGELES -- Will Ferrell’s animated comedy “Megamind” debuted as the No. 1 movie with $47.7 million.

Along with the voices of Brad Pitt, Tina Fey and Jonah Hill, the DreamWorks Animation release has Ferrell’s title character hatching a scheme to fill the void in his life after he finally defeats his superhero nemesis.

Robert Downey Jr. and Zach Galifianakis’ road-trip comedy, “Due Date,” opened at No. 2 with $33.5 million. The Warner Bros. romp features the two stars as mismatched traveling companions who hit the highway from Atlanta to Los Angeles.

Tyler Perry’s drama “For Colored Girls,” whose ensemble cast features Janet Jackson and Whoopi Goldberg, premiered in third-place with $20.1 million.

Estimated ticket sales for Friday through Sunday at U.S. and Canadian theaters.

1. “Megamind,” $47.7 million.

2. “Due Date,” $33.5 million.

3. “For Colored Girls,” $20.1 million.

4. “Red,” $8.9 million.

5. “Saw 3D,” $8.2 million.

6. “Paranormal Activity 2,” $7.3 million.

7. “Jackass 3D,” $5.1 million.

8. “Hereafter,” $4.02 million.

9. “Secretariat,” $4 million.

10. “The Social Network,” $3.6 million.