NEW ORLEANS — Wil Lutz kicked a 44-yard field goal for New Orleans with 21 seconds left, Cleveland kicker Zane Gonzalez pushed the second of his two missed field goals wide right in the final seconds, and the Saints held on for a 21-18 victory that extended the Browns’ winless streak to 19 games.

Gonzalez also missed two extra points,.

Cleveland (0-1-1) carried a two-score lead into the final nine minutes before its latest collapse.

Receiver Michael Thomas had two fourth-quarter touchdowns for the Saints (1-1), who scored 40 points in a Week 1 loss to Tampa Bay, but didn’t find the end zone against Cleveland until 8:41 remained.

Thomas’ 2-yard catch cut Cleveland’s lead to 12-10.

Marcus Williams’ interception of Tyrod Taylor with just less than five minutes remaining set up Thomas’ leaping 5-yard touchdown catch with 2:40 to go, and Alvin Kamara’s run for a 2-point conversion put the Saints up 18-12.

That conversion made all the difference after Taylor found Antonio Callaway with a 47-yard, all-or-nothing heave on fourth-and-5 with 1:16 to go. Gonzalez missed a point-after kick for the second time, and Drew Brees’ 42-yard completion to Ted Ginn Jr. set up Lutz’ go-ahead kick.

Vikings 29, Packers 29

GREEN BAY, Wis. — Daniel Carlson missed two field goals in overtime, including one from 35 yards as time expired, and the Vikings had to settle for a 29-29 tie after rallying from a late 13-point deficit.

The rookie pushed his final kick wide right, just like his attempt from 49 earlier in overtime.

Bucs 27, Eagles 21

TAMPA, Fla. — Ryan Fitzpatrick threw for more than 400 yards and four touchdowns for the second straight week.

Jaguars 31, Patriots 20

JACKSONVILLE, Fla. — Blake Bortles threw four touchdown passes, three in the first half, and the Jaguars(2-0) beat Tom Brady and the Patriots in a rematch of last season’s AFC championship game.

Bortles connected with Donte Moncrief, Keelan Cole and Austin Seferian-Jenkins for scores in the first 30 minutes.

Broncos 29, Raiders 19

DENVER — Brandon McManus kicked a 36-yard field goal just inside the right upright with 6 seconds left, denying Jon Gruden his first win as a head coach since 2008.

Rams 34, Cardinals 0

LOS ANGELES) — Todd Gurley ran for three touchdowns, Jared Goff threw for 354 yards and a touchdown.

The Rams have won their first two games for the first time since 2001, when they went to the Super Bowl.

49ers 30, Lions 27

SANTA CLARA, Calif. — Jimmy Garoppolo threw two touchdown passes, Matt Breida ran for 138 yards and San Francisco’s longest TD run in four seasons , and the 49ers bounced back from a season-opening loss.

Falcons 31, Panthers 24

ATLANTA — Matt Ryan ran for a pair of scores for the first time in his career and threw a pair of TD passes.

Ryan finished 23 of 28 passing for 272 yards.

Dolphins 20, Jets 12

EAST RUTHERFORD, N.J. — Ryan Tannehill threw two touchdown passes, Kenyan Drake ran for a score and the Dolphins took advantage of several mistakes by Sam Darnold and the Jets.

Chargers 31, Bills 20

ORCHARD PARK, N.Y. — Melvin Gordon matched a career high by scoring three touchdowns, and the Chargers manhandled the anemic Bills during rookie quarterback Josh Allen’s debut as a starter.

Titans 20, Texans 17

NASHVILLE, Tenn. (AP) — Ryan Succop kicked a 31-yard field goal with 1:00 left, and the battered Titans held off the Texans 20-17 to give Mike Vrabel his first victory as an NFL head coach.

Colts 21, Redskins 9

LANDOVER, Md. — Andrew Luck threw for two touchdown passes, shook off two interceptions and engineered a game-sealing drive.

Luck was 21 of 31 for 179 yards and had a TD pass in a 25th consecutive game.