For Colts quarterback Peyton Manning, engineering fourth-quarter comebacks has become almost routine during his career.

For Jake Delhomme, it’s becoming commonplace this season for the surprising Panthers.

Manning led Indianapolis back from a 15-0, second-half deficit, and the Colts edged the Vikings 18-15 on Adam Vinatieri’s 47-yard field goal with 3 seconds left on Sunday.

Avoiding his first 0-2 start since his rookie season in 1998, Manning zinged a 20-yard pass on third-and-9 to Reggie Wayne up the seam before Vinatieri — who uncharacteristically missed a 30-yarder earlier — kicked the game-winner.

“That’s one of the most satisfying wins I’ve had, definitely, since I’ve been in Indianapolis,” coach Tony Dungy said. “It wasn’t the most artistic, and I told the team we’ve got a lot of glass-half-empty, glass-half-full stuff, but I was very, very proud of our effort.”

The Vikings (0-2) wasted more dominant defense, done in by a handful of critical lapses and repeated failure to figure out that pesky forward pass. Adrian Peterson rushed for 118 of his 160 yards in the first half, and Minnesota was across midfield on its first eight possessions.

The prize for that? Five field goals by Ryan Longwell and three punts.

“It’s real frustrating,” said wide receiver Bernard Berrian, who had no catches. “It’s kind of embarrassing, actually, to go out there and just have field goals all day. We’re moving the ball up and down the field, really, at will. ... The defense played their hearts out today. They did everything they could. I mean, they really handed us the game and we blew it.”

Manning hasn’t looked his usual sharp self this September following summer knee surgery. He finished 26-for-42 for 311 yards, one touchdown and two interceptions.

Jonathan Stewart rushed for all but one of his 77 yards in the second half and scored two touchdowns, including the go-ahead TD late in the fourth quarter, and the Panthers stopped the Bears (1-1) on fourth-and-1 with less than 2 minutes left in the 20-17 win.

The Panthers (2-0) scored the game’s final 17 points, recovering from a mistake-prone first half, behind their improved defense.

Jason Campbell, Aaron Rodgers, Trent Edwards and Jay Cutler also led their teams to impressive comeback wins on Sunday.

Redskins 29, Saints 24Jason Campbell went from uncomfortable to prolific, completing 24 of 36 passes for 321 yards in a victory over visiting New Orleans.The big play came with 3:29 left and the Redskins trailing 24-22. Campbell avoided the rush, stepped forward and hit Santana Moss in stride, the receiver one step ahead of cornerback Tracy Porter, for a 67-yard touchdown.

Packers 48, Lions 25Aaron Rodgers threw three touchdown passes in the first four drives of his second start, helping Green Bay (2-0) build a big lead in a win over host Detroit.

Bills 20, Jaguars 16Trent Edwards completed his first 10 attempts and threw a perfect touchdown pass to James Hardy late in the fourth quarter, as the visiting Bills beat beleaguered Jacksonville.Edwards finished 20-of-25 for 239 yards, Marshawn Lynch ran for 59 yards and a score, and Buffalo’s defense held Jacksonville in check most of the day.

Broncos 39, Chargers 38Showing ultimate confidence in his offense, Mike Shanahan went for a 2-point conversion with 29 seconds left and Jay Cutler hit rookie Eddie Royal over the middle to give host Denver a win.The Chargers (0-2) lost in the final seconds for the second straight week.

49ers 33, Seahawks 30, OTJoe Nedney shook off a missed field goal as time expired in regulation and kicked a 40-yarder 4:40 into overtime, sending San Francisco past host Seattle.

Patriots 19, Jets 10Matt Cassel was efficient running the offense in his first NFL start, taking over for the injured quarterback and leading the visiting Patriots over Brett Favre and the Jets.

Giants 41, Rams 13Eli Manning threw three touchdown passes and the visiting Giants (2-0) sacked Marc Bulger six times in another poor performance by the Rams offensive line.

Titans 24, Bengals 7Backup quarterback Kerry Collins threw low, tight passes that stayed on track in Cincinnati’s wind-tunnel of a stadium, setting up a victory for the Titans (2-0).

Raiders 23, Chiefs 8Rookie Darren McFadden ran for 164 yards and a touchdown and Sebastian Janikowski kicked a team-record 56-yard field goal, leading the visiting Raiders over an inept Chiefs team that tried three quarterbacks.

Cardinals 31, Dolphins 10Kurt Warner completed 19 of 24 passes for 361 yards and three touchdowns to Anquan Boldin, and host Arizona is 2-0 for the first time in 17 years after routing Miami.

Buccaneers 24, Falcons 9A week after beating Detroit in his pro debut, Matt Ryan threw incompletions on his first nine passes before settling down to keep Atlanta (1-1) in the game with three field goal drives that trimmed a 17-point deficit to eight.