Brett Favre and the New York Jets made their statement to the league by toppling the NFL's last undefeated team.

Now that they've knocked off Tennessee — something no one else this year has managed to do — what other AFC titans might they be ready to slay?

If the Jets can hang on to their division lead, they might just find out — especially with more games like they had Sunday. Favre threw two touchdown passes, Leon Washington ran for two scores and the New York Jets routed the Titans 34-13.

"It felt like we were on the sideline forever just watching Brett Favre play," Titans fullback Ahmard Hall said. "The defense, I felt bad that we on offense couldn't get anything going and keep them off the field."

One perfect team does remain in the NFL, though: The Detroit Lions came close to ending their unbroken run of losses to start the season by taking an early 17-point lead, but they managed to lose to Tampa Bay 38-20.

In Nashville, Tenn., the Jets (8-3) came in atop the AFC East after a victory over New England at Foxborough. They have won five straight for the first time since October 2004 and seven of their last eight. The win also got them within two of Tennessee (10-1) with five to play in the race for home-field advantage through the playoffs.

"Now people are going to start looking at us and say, 'They are a team you have to reckon with,"' Jets linebacker Bryan Thomas said.

The Titans had won 13 straight regular-season games dating to Dec. 16, 2007, becoming only the 11th team since 1970 to win its first 10 games.

"It was a great run, and we've got to win our next game," Titans coach Jeff Fisher said.

At San Diego, Adam Vinatieri made a 51-yard field goal as time expired to lift Peyton Manning and the Colts to a heart-stopping win over the Chargers.Manning threw two touchdown passes for the Colts (7-4), who won their fourth straight.San Diego (4-7) has lost four of five and remains two games behind division leader Denver.

At Detroit, Tampa Bay fell behind the winless Lions by 17 points, then scored five unanswered touchdowns en route to its third straight victory.Warrick Dunn ran for a touchdown and Jeff Garcia connected with Ike Hilliard and Jerramy Stevens for scores in the second quarter to put the Buccaneers (8-3) ahead 21-17.

At Miami, Matt Cassel threw for 415 yards, Randy Moss caught three touchdown passes and the resilient Patriots avoided being swept in a season series by a division opponent for the first time since 2000.The loss snapped a four-game winning streak for the Dolphins (6-5).

At Irving, Texas, Terrell Owens broke out with seven catches for 213 yards, helping Dallas to consecutive victories for the first time since a 3-0 start.Owens' total was the second-highest of his career — he had 283 yards and caught an NFL-record 20 passes against the 49ers in 2000 — and tied for fourth-best in Cowboys history.

At Baltimore, Donovan McNabb watched from the sideline as Baltimore gave first-year coach John Harbaugh a lopsided victory over the team he served as an assistant for 10 years.Ed Reed picked off McNabb's replacement, Kevin Kolb, and returned the interception an NFL-record 108 yards for a touchdown to give Baltimore (7-4) a 22-point cushion with 7:24 left.

At Kansas City, Mo., Trent Edwards threw for two touchdowns, ran for two others and Buffalo rang up more points than had ever been scored against Kansas City.

At Jacksonville, Fla., Adrian Peterson ran for 80 yards and a touchdown, and the Vikings used two scores in the first 1:41 to beat Jacksonville.Jacksonville had five turnovers, none more costly than two fumbles to open the game.

At Cleveland, Sage Rosenfels passed for 275 yards and a touchdown, and Kris Brown kicked three field goals as Houston snapped an eight-game losing streak outside Texas.

At St. Louis, rookie Matt Forte had a season-high 132 yards rushing and scored on two long runs, and Marc Bulger lasted only five plays before sustaining a concussion against a defense that had three of a season-best five sacks by the break.

At Glendale, Ariz., Eli Manning threw for three TDs in his return to the scene of his Super Bowl MVP performance, and the Giants snapped the Cardinals' seven-game home winning streak.

At Denver, Ashley Lelie, who forced a trade out of Denver in 2006 after a bitter holdout, returned to Invesco Field and helped lead Oakland to a stunning win over the Broncos by catching a touchdown pass and setting up another with a spectacular 51-yard reception.

At Atlanta, Michael Turner scored four touchdowns and rookie Harry Douglas scored his first career TD on a 7-yard end-around, caught a 69-yard pass that set up a TD, then finished off the Panthers with a 61-yard punt return.

At Seattle, Clinton Portis darted and pounded for 143 yards on 29 carries, including key runs late that helped preserve the Redskins' first victory in almost a month.Portis' status was questionable during the week.