WASHINGTON — In the span of just 10 days, FBI Director James B. Comey managed to irk his current boss, upset two potential future ones, enrage congressional overseers in both political parties and spark a national debate about the bureau’s politicization.

So it’s hardly surprising that Washington’s latest parlor game is speculating about the future of the 55-year-old former prosecutor, once praised for independence and integrity but now facing calls for his resignation.

On Sunday, Comey took the extraordinary step of reaffirming his agency’s July conclusion that Hillary Clinton should not be prosecuted over her handling of classified material while serving as secretary of State. That was barely a week after he rocked the 2016 presidential race by announcing that the bureau would investigate newly discovered e-mails possibly related to the private e-mail server she used.

His actions, so close to Tuesday’s vote, frustrated liberals and conservatives alike. Democrats said Comey should have gathered more facts about the new e-mails before making a public announcement; most of the e-mails on a computer used by Clinton aide Huma Abedin turned out to be duplicates or unrelated to the investigation. Republicans, who heralded Comey for launching the new inquiry, quickly changed course and accused him of buckling under pressure.

By alienating both sides, Comey may be able to neutralize some of the growing concerns about whether his agency is the latest Washington institution to fall victim to partisanship. But it also raises questions about what kind of relationship Comey will have with the next president, no matter who wins.

Just three years into his 10-year term, Comey, a Republican who served in President George W. Bush’s Justice Department and was appointed to lead the FBI by President Barack Obama, is believed to want to soldier on, finishing programs he put in motion to reshape the agency amid new and evolving threats.

But it’s unclear whether he will enjoy the trust or support of the next president, since both Clinton and Donald Trump have at times questioned his motives and judgment.

Relations with Clinton would be particularly fraught since she would enter office as Comey’s boss after being in his investigative crosshairs over her handling of classified materials, which he derided as “extremely careless” though not worthy of prosecution.

Clinton, in turn, said Comey’s vague Oct. 28 missive to Congress to announce the bureau would examine the new e-mails was “unprecedented” and “deeply troubling.”

“Honestly, the difficulty will be the shadow and ghosts of the email investigation, and they are going to come into the room every time he meets with the president,” said Ronald Hosko, who worked for Comey as one of his top deputies.