BRADENTON, Fla. — A.J. Burnett had little trouble the first time through Boston’s batting order. The second time around was different.

Burnett left with runners on in the third inning, David Ortiz and Pablo Sandoval followed with home runs off Ryan Beckman and the Red Sox beat the Pittsburgh Pirates 5-1 Thursday.

After starting with two hitless innings, Burnett walked Blake Swihart and Shane Victorino opening the third. Dustin Pedroia flied out and Beckman relieved.

As Burnett walked off the mound, the 38-year-old right-hander looked at Ortiz and shrugged.

“Did they take me out because you’re up?” he asked.

Ortiz took two strikes from Beckman and homered his third pitch over the center-field wall for a 3-1 lead.