INDIANAPOLIS — Andrew Luck capped a second-half comeback by throwing a 4-yard touchdown pass to Reggie Wayne with 35 seconds to go that gave Indianapolis a stunning 30-27 victory over Green Bay on Sunday in the Colts’ first game without coach Chuck Pagano.

Green Bay (2-3) had a chance to force overtime, but Mason Crosby missed a 51-yard field goal with 3 seconds to go. Luck then took a knee and time ran out and the team celebrated. Missing was Pagano, who is in a hospital undergoing treatment for leukemia that was recently diagnosed.

Luck came through with just what Pagano wanted — getting the Colts (2-2) to .500. And they did it despite trailing 21-3 at halftime.

Saints 31, Chargers 24

NEW ORLEANS — Drew Brees threw for 370 yards and broke a half-century-old NFL record by throwing a touchdown pass in his 48th straight game, and New Orleans won for the first time this season with a victory over San Diego.

Brees’ 40-yard pass to Devery Henderson eclipsed the mark of 47 consecutive games with a touchdown pass set by Johnny Unitas from 1956-60. Brees’ also had three scoring strikes to Marques Colston, giving him a franchise-record 52 touchdown catches with the Saints (1-4).

Falcons 24, Redskins 17

LANDOVER, Md. — Michael Turner ran 13 yards for the go-ahead score with 2:46 to play, and Atlanta knocked Robert Griffin III out of the game.

The Falcons are 5-0 for the first time in franchise history.

Patriots 31, Broncos 21

FOXBOROUGH, Mass. — Tom Brady won his latest showdown with Peyton Manning with the help of a career-high 151 yards rushing from Stevan Ridley.

In the 13th meeting between the star quarterbacks, and first since Manning left the Indianapolis Colts, Brady directed four scoring marches of at least 80 yards and the Patriots rushed for 252 yards.

Dolphins 17, Bengals 13

CINCINNATI — Reshad Jones intercepted Andy Dalton’s overthrown pass at midfield with 1:22 left, preserving a win that ended two weeks of miserable, last-minute finishes for Miami.

Giants 41, Browns 27

EAST RUTHERFORD, N.J. — Victor Cruz and Ahmad Bradshaw set career bests in leading New York Giants over winless Cleveland.

Cruz caught three touchdown passes from Eli Manning covering 3, 7 and 28 yards, while Bradshaw surpassed his yardage on the ground for the season with a career-high 200. He had 132 entering the game.

Vikings 30, Titans 7

MINNEAPOLIS — Percy Harvin pounded his way through Tennessee’s defense for one touchdown rushing and another receiving for Minnesota.

Harvin caught eight passes for 108 yards for the Vikings (4-1), who have given up a combined 33 points in winning three straight games. Christian Ponder threw his first two interceptions after 143 attempts without one, but he still finished 25 for 35 for 258 yards and two scores against the reeling Titans (1-4).

49ers 45, Bills 3

SAN FRANCISCO — Alex Smith threw for a season-high 303 yards and three touchdowns, Frank Gore ran for 106 yards and a score, and San Francisco amassed a franchise-record 621 yards.

Michael Crabtree and Vernon Davis each eclipsed 100 yards receiving to back Smith, who threw TD passes of 43, 28 and 10 yards and surpassed 300 yards passing for only the third time in his career.

Bears 41, Jaguars 3

JACKSONVILLE, Fla. — Charles Tillman and Lance Briggs returned interceptions for touchdowns — their second in six days — and Chicago used stifling defense to overwhelm Jacksonville.

The Bears (4-1) scored 38 unanswered points in the second half to win their third consecutive game. The streak has everything to do with defense.

Seahawks 16, Panthers 12

CHARLOTTE, N.C. — Russell Wilson threw a 13-yard touchdown pass to Golden Tate with 35 seconds left in the third quarter and Seattle came up with four sacks against Cam Newton.

Wilson shook off two third quarter interceptions — including one that was returned for a touchdown.

Ravens 9, Chiefs 6

KANSAS CITY, Mo. — Ray Rice ran for 101 yards and Justin Tucker made all three of his field goal attempts.

Joe Flacco threw for 187 yards and was picked off once, but the Ravens (4-1) were still able to come up with enough points to beat the Chiefs (1-4), who turned it over four times.