LOS ANGELES — Supported by real-life romantic splits and hookups, Jennifer Aniston and Vince Vaughn's "The Break-Up" pulled an upset over the mutant world of the "X-Men."

"The Break-Up" debuted more strongly than expected with $38.1 million to take over as the No. 1 weekend movie from "X-Men: The Last Stand," which slipped to second place with $34.35 million.

Aniston's split from Brad Pitt last year and her reported romance that began with Vaughn while filming "The Break-Up" helped keep the movie in the public eye.

DreamWorks Animation's cartoon comedy "Over the Hedge" held up well, placing third with $20.6 million.

Estimated ticket sales for Friday through Sunday:

1. "The Break-Up," $38.1 million.

2. "X-Men: The Last Stand," $34.35 million.

3. "Over the Hedge," $20.6 million.

4. "The Da Vinci Code," $19.3 million.

5. "Mission: Impossible III," $4.67 million.

6. "Poseidon," $3.4 million.

7. "RV," $3.3 million.

8. "See No Evil," $2 million.

9. "An Inconvenient Truth," $1.33 million.

10. "Just My Luck," $825,000.