While Brett Favre sets records and stunningly has the Green Bay Packers at the top of their conference, a bunch of other NFL teams are surprisingly heading the other way.

Take the 2006 NFC champion Chicago Bears, whom Detroit beat 37-27 on Sunday. Or the supposedly powerful San Diego Chargers, who fell into the AFC West cellar with a 30-16 home less to Kansas City.

With yet another vintage performance, Favre surpassed Dan Marino's career record for touchdown passes and led Green Bay (4-0) over the host Vikings (1-3).Favre threw TD pass No. 421 in the first quarter, a 16-yarder to Greg Jennings, and No. 422 in the fourth quarter to James Jones.

The Bears (1-3) kept reeling at Detroit. Jon Kitna threw two touchdown passes in the fourth quarter, when the Lions (3-1) scored a league-record 34 points.

At San Diego, the Chiefs (2-2) scored 24 straight points in the second half. Rookie receiver Dwayne Bowe, the Chiefs' first-round draft pick, caught a go-ahead, 51-yard touchdown pass from Damon Huard.

Depleted Buffalo got its first victory after three defeats. In his first career start in place of injured J.P. Losman, Trent Edwards went 22-of-28 for 234 yards.

New York (2-2) took full advantage of injuries to the visiting Eagles, who were without stars Brian Dawkins and Brian Westbrook. The Giants tied an NFL mark with 12 sacks, six by end Osi Umenyiora.

Tony Romo had a 15-yard touchdown run and threw TD passes of 59, 37 and 17 yards. Patrick Crayton scored the first two touchdowns.

At Indianapolis, the Colts scored on six of their last eight possessions. Peyton Manning finished 20-of-27 for 193 yards and three touchdowns, while Joseph Addai ran 19 times for 136 yards and one score.

Jeff Garcia didn't throw an interception for the fourth straight game and ran for a touchdown as visiting Tampa Bay (3-1) moved atop the NFC South.

At San Francisco, Matt Hasselbeck passed for 281 yards and two touchdowns, Rocky Bernard's hit separated Alex Smith's right shoulder, and the Seahawks (3-1) took the lead in the NFC West.

At Cleveland, Derek Anderson threw two touchdown passes and Jamal Lewis ran for one against his former team, as the Browns improved to 2-2.

At Miami, Daunte Culpepper ran for three touchdowns and threw for two to win the grudge game against his former team.

Joey Harrington threw a pair of touchdown passes to Michael Jenkins, 47-year-old Morten Andersen kicked four field goals.