Roger Clemens was done in by the Houston Astros' bullpen again.

The Rocket left with a four-run lead, but Garrett Atkins' eighth-inning grand slam off Russ Springer led the Colorado Rockies to a 6-5 victory Tuesday night.

It was the third time this season Clemens left with Houston ahead, but the relievers failed to hold the lead.

"You can't let that stuff bother you because I've been beat every which way you can think of," Clemens said. "They made me look good a number of times when I have only been able to go seven or not get it to the eighth, and I try to make them all aware of the fact that I am going to need help each night. I think my complete games are pretty much over."

Morgan Ensberg had a grand slam and five RBI to back the 42-year-old Clemens, who leads the major leagues with a 1.50 ERA but is just 6-3.

Clemens allowed a fourth-inning homer to Preston Wilson - the first run off the Rocket on the road in 49

innings since Sept. 14 at St. Louis.

"It was disappointing to see it get away, because once again he had another marvelous outing," Houston manager Phil Garner said.

At Coors Field, Houston's Craig Biggio was hit by a pitch in the fifth inning against Jason Jennings, tying Don Baylor's post-1900 major league record of 267 times getting hit. Biggio has been hit 11 times this season - his 10th time in double digits in 12 seasons.

Marcus Giles hit the first home run off Dontrelle Willis (12-3) in 12 starts since April 23 as visiting Atlanta won its fifth straight.Willis, trying to become the first 13-game winner in the majors, allowed five runs and 11 hits in seven innings. His ERA rose to 2.04.

Carlos Zambrano (5-4) allowed three hits in eight innings at Wrigley Field and Derrek Lee, who leads the major leagues with a .387 average, hit his 23rd homer as Chicago won its third straight. Ryan Dempster worked a perfect ninth for his 12th save.

Mike Piazza drove in three runs with a single and his ninth homer, and Carlos Beltran had a double and triple for New York, which has won four of five.

Jason Schmidt outpitched Brad Halsey for the second time in six days as visiting San Francisco rebounded from Sunday's 16-0 loss to Oakland and stopped a four-game losing streak.

Brian Lawrence improved to 10-5 against Los Angeles, allowing two runs and five hits in 7 1-3 innings. Robert Fick drove in three runs for visiting San Diego.Elmer Dessens (0-1) allowed three runs - one earned - in five innings.Cardinals 2, Reds 1Mark Mulder (9-5) gave up one run and seven hits in 6 1-3 innings, and Reggie Sanders backed him with a come-from-behind, two-run homer in the first off Brandon Claussen (4-5). Cincinnati has lost 15 of its last 17 road games.

At Baltimore, Brian Roberts homered on Mike Stanton's first pitch in the 10th inning and Baltimore snapped a six-game losing streak by beating New York.Rafael Palmeiro also hit a memorable shot, his 563rd homer to tie Reggie Jackson for ninth on the career list.

Garrett Anderson tied Joe Rudi's team record for grand slams with his seventh, and it came at the perfect time. He connected in the 11th inning off lefty Brian Shouse to lift Los Angeles over Texas for its eighth straight victory.

Travis Hafner hit a grand slam off Keith Foulke (5-4) in a five-run ninth inning, doubled twice and drove in six runs to lead Cleveland over Boston at Fenway Park.

At Detroit, Mark Buehrle outpitched Nate Robertson (3-6) to win his ninth straight decision, and Jermaine Dye hit a tiebreaking homer. Buehrle (10-1) allowed one run in 6 2-3 innings, lowering his ERA to 2.42. Dustin Hermanson escaped a ninth-inning jam for his 18th save in 19 chances.

At St. Petersburg, Fla., defensive replacement Gabe Gross bailed Toronto out of one last jam and John McDonald snapped an 11th-inning tie with an infield hit.

At Minneapolis, Shannon Stewart had three hits and three RBIs, including a go-ahead single in the seventh to hand Kansas City its eighth consecutive loss. Jesse Crain (7-0) continued his dominance in middle relief with 1scoreless innings. Joe Nathan earned his 20th save in 22 tries.

At Oakland, Calif., Marco Scutaro homered and Barry Zito (4-8) earned the ninth straight win by an A's starter, leading them to their season-high fifth consecutive victory.