NEW ORLEANS — Robert Griffin III began his NFL career by connecting on 19 of 26 passes for 320 yards and two touchdowns, and the Washington Redskins handed the Saints a 40-32 loss in their first game since the bounty scandal that overshadowed New Orleans’ offseason.

Griffin completed his first eight passes, including an 88-yard touchdown pass to Pierre Garcon, tying for the second-longest scoring pass by a quarterback making his NFL debut.

Bears 41, Colts 21

CHICAGO — Jay Cutler threw for 333 yards and two touchdowns and Michael Bush added a pair of scoring runs to spoil quarterback Andrew Luck’s debut.

Brandon Marshall had nine catches for 119 yards and a touchdown in his first game since being reunited with Cutler, and Matt Forte ran for 80 yards and a score.

49ers 30, Packers 22

GEEN BAY, Wis. — San Francisco’s defense smothered Aaron Rodgers and the Green Bay offense for most of the game, then made one last stand to stop a late rally.

The Packers rallied from a 16-point deficit in the fourth quarter, and pulled within eight points when Aaron Rodgers threw a touchdown pass to James Jones with 6:05 left, but the 49ers defense held the Packers in the final minute to come away with a big win to open the season.

Eagles 17, Browns 16

CLEVELAND — Michael Vick overcame four interceptions by throwing a 4-yard touchdown pass to Clay Harbor with 1:18 left in the nerve-racking win.

Vick led the Eagles on a 91-yard scoring drive, capping it with his short toss to Harbor on his career-high 56th pass.

Vikings 26, Jags 23, OT

MINNEAPOLIS — Rookie Blair Walsh kicked four field goals, including a 55-yarder as regulation time expired and another one in overtime, and Adrian Peterson returned from a left knee injury to score two TDs and lift the Vikings.

Lions 27, Rams 23

DETROIT — Matthew Stafford threw a 5-yard touchdown pass to Kevin Smith with 10 seconds left.

Stafford made up for a shaky game by leading an 80-yard, nine-play, game-winning possession that included three passes of at least 18 yards.

Jets 48, Bills 28

EAST RUTHERFORD, N.J. — Mark Sanchez threw three touchdown passes, including two to rookie Stephen Hill, and the Jets eased concerns about their offense.

The Jets sprinkled in their wildcat package with Tim Tebow, who was mostly quiet but recovered a late onside kick by Buffalo, and Jeremy Kerley had a touchdown catch and a punt return for a score. Antonio Cromartie also took one of New York’s three interceptions of Ryan Fitzpatrick to the end zone.

Texans 30, Dolphins 10

HOUSTON — Arian Foster had two touchdown runs, Matt Schaub threw a TD pass to Andre Johnson, and Houston’s defense dominated rookie Ryan Tannehill and Miami.

Tannehill threw three interceptions in a 6-minute stretch late in the first half, and the Texans opened impressively in what they believe can be a Super Bowl season.

Patriots 34, Titans 13

NASHVILLE, Tenn. — Tom Brady threw for 236 yards and two touchdowns, and the defending AFC champions won easily.

The Patriots ruined Jake Locker’s debut as Tennessee’s starter. Locker came out of the game after hurting his left shoulder when tackling safety Patrick Chung on a fumble return. He was replaced by Matt Hasselbeck.

Falcons 40, Chiefs 24

KANSAS CITY, Mo. — Matt Ryan threw for 299 yards and three touchdowns, one of them to Tony Gonzalez in his return to Kansas City.

Bucs 16, Panthers 10

TAMPA, Fla. — Tampa Bay’s rejuvenated defense came up with two interceptions against Cam Newton and the Buccaneers won their debut under coach Greg Schiano.

Cards 20, Seahawks 16

GLENDALE, Ariz. — Kevin Kolb replaced injured John Skelton and led Arizona on the deciding touchdown drive, throwing 6 yards to Andre Roberts for a score with 4:59 to play.