Attorney General Josh Shapiro has finalized agreements with CVS and Walgreens to bring the national amount from investigations and litigation against the pharmaceutical industry for its role in the opioid crisis to more than $54.1 billion, with $2.2 billion coming directly to Pennsylvania.

A Monday news release from Shapiro’s office said Pennsylvania’s share of the CVS and Walgreens settlements is more than $450 million, with the additional funds coming from Walmart, Teva and Allergen, and the firms in bankruptcy, including Purdue, Malinckrodt and Endo. Under the agreements, CVS will pay $5 billion and Walgreens will pay $5.7 billion, totaling $10.7 billion.

The agreement is the result of a multistate investigation into manufacturers, distributors and pharmacies for their roles in the opioid epidemic. That investigation has led to $54.1 billion in settlement agreements with opioid manufacturers and distributors.