Barry Zito and Brad Penny were roughed up out West, while Roger Clemens' comeback got off to a strong start in the minors.

On the first night of interleague play this season, Detroit routed St. Louis 14-4 in a World Series rematch and several top pitchers were on display. But Zito and Penny, two of those aces, were way off their game.

In his dreadful return to the Oakland Coliseum, Zito never guessed the strike zone would be tougher to find than the visitors' clubhouse. The Athletics hammered him for seven runs and six hits Friday in a 15-3 victory over the San Francisco Giants to open the Bay Bridge Series.

Zito (3-5) also issued seven of the Giants' 13 walks during an awful night for the club and its $126 million left-hander, who couldn't get an out in the fifth inning. He got a mixed reception from Oakland fans.

"It was kind of strange, (but) I don't know if my emotions played into it," said Zito, who won 102 games and the 2002 AL Cy Young Award during seven seasons with the A's. "It creeps into your mind that it's a different situation, but it's my job to block that out and treat them as normal opponents."

Penny (5-1) also struggled, giving up eight runs and eight hits in five-plus innings during the Los Angeles Angels' 9-1 victory over the Dodgers in the Freeway Series opener at Anaheim, Calif.

The right-hander's ERA jumped from a major league-best 1.39 to 2.54. In his previous eight starts this year, he allowed a total of eight earned runs.

"You know you're going to lose a game. I don't care if I give up 10 runs or one run and lose, it's the same result," Penny said. "I wasn't horrible. I was around the plate, but I wasn't locating as well as I have been in the past."

Clemens is four innings closer to his major league return, and pushing himself relentlessly.

With New York Yankees owner George Steinbrenner watching from a private box at Legends Field in Florida, Clemens threw 58 pitches and gave up only a solo homer for Class-A Tampa in the first minor league start of his latest comeback.

"Right now I'm in high gear. In the next four or five days, hopefully I'll be able to step back and get a grasp on everything," Clemens said.

"I've pushed my body to a point now in the last three weeks that hopefully I can start trying to retain some energy so I can get a little better results when I get on the mound."

Tigers 14, Cardinals 4

At Detroit, Andrew Miller (1-0) pitched six scoreless innings in his first major league start and the Tigers scored nine runs in the fifth to gain a small measure of satisfaction after losing the 2006 World Series to St. Louis in five games.

Gary Sheffield and Magglio Ordonez homered early for the Tigers.

Cubs 6, White Sox 3

At Chicago, Angel Pagan hit a tying triple in the seventh and scored the go-ahead run on a passed ball at Wrigley Field. Backup catcher Toby Hall, playing his first game behind the plate this season after coming back from a shoulder injury, had two errors and the passed ball that cost the White Sox.

Mets 3, Yankees 2

At New York, Endy Chavez's first home run of the year, a go-ahead, two-run shot off Andy Pettitte (2-3) in the fifth at Shea Stadium, led the Mets to a victory that dropped their crosstown rival 10 games back in the AL East for the first time in the Joe Torre era.

Oliver Perez (5-3) limited the Yankees to Hideki Matsui's two-run homer in the fourth.

Marlins 8, Devil Rays 4

At St. Petersburg, Fla., Byung-Hyun Kim (2-2) won his Marlins debut and Aaron Boone hit a grand slam off Edwin Jackson (0-6), ending Tampa Bay's four-game winning streak.

Indians 9, Reds 4

At Cleveland, Ryan Garko and Grady Sizemore homered to help Cliff Lee (2-0) improve to 8-0 in interleague play. Garko hit a three-run homer off Kyle Lohse (1-5) and Sizemore had four hits.

Phillies 5, Blue Jays 3

At Philadelphia, Jon Lieber (2-2) pitched seven-plus strong innings and Brett Myers escaped a bases-loaded jam for his fifth save

Orioles 5, Nationals 4

At Washington, Brian Roberts tied a career high with four hits, Steve Trachsel (2-3) won for the first time in five starts and Baltimore snapped a five-game skid. Chris Ray got his ninth save.

Twins 8, Brewers 1

At Milwaukee, Boof Bonser (2-1) struck out a career-high 11 in seven innings and Torii Hunter hit his second grand slam this season to help Minnesota win for only the third time in 11 games.

Rangers 7, Astros 4

At Houston, Nelson Cruz and Ramon Vazquez hit consecutive homers, and Robinson Tejeda (4-3) held the Astros hitless for five innings. Sammy Sosa added a two-run double and Eric Gagne earned his second save.

Royals 5, Rockies 2

At Denver, Emil Brown hit a tiebreaking, three-run homer to highlight Kansas City's five-run eighth. Joakim Soria got his ninth save.

Padres 8, Mariners 1

At Seattle, Kevin Kouzmanoff hit a two-run double for an early lead and Chris Young (5-3) made it stand up. Russell Branyan added a three-run homer.