KANSAS CITY, Mo. — One of the few things Patrick Mahomes hadn’t done in his young career was bounce back from a loss.

He made that look just as easy as Mahomes does everything else.

The Chiefs’ young record-setting quarterback threw for 358 yards and four touchdowns Sunday night, Kareem Hunt finished with three scores and Kansas City rebounded from a last-second loss in New England by throttling the Cincinnati Bengals 45-10.

Mahomes was 28 of 39 with his only big mistake an underthrown interception, though the Chiefs (6-1) were already so far ahead of Cincinnati (4-3) by that point it didn’t really matter.

He spread the wealth, too, connecting with eight targets. Tyreek Hill had seven catches for 68 yards and a touchdown, and Demetrius Harris hauled in the other TD catch.

The Bengals’ Andy Dalton was held to just 148 yards passing with a touchdown and an interception by the NFL’s worst defense. Joe Mixon managed just 50 yards rushing.

The Chiefs, wearing their all-red uniforms for the prime-time matchup, flexed some rare defensive muscle to open the game, creating a three-and-out for their first forced punt in 17 possessions.