Emmanuel Sanders threw and caught touchdown passes, Denver returned two interceptions for first-quarter touchdowns and the Broncos snapped a four-game losing streak with a 45-10 rout of the Arizona Cardinals on Thursday night.

Todd Davis returned rookie Josh Rosen’s deflected pass for a touchdown on the second play of the game and Chris Harris Jr. took another back 53 yards for a score with 2:02 left in the quarter as the Broncos (3-4) opened a 21-3 lead.

Rosen threw three interceptions and fumbled the ball away twice on a rough night that began badly for him and never got better.

The Cardinals (1-6), down 35-3 at the half, fell to 0-4 at home for the first time since 1979.