SAN DIEGO — Eric Hosmer stood in the middle of the field, holding up a trophy. He hopes to do it again with the Kansas City Royals this fall.

Hosmer and Salvador Perez homered off former Kansas City teammate Johnny Cueto during a six-pitch span in the second inning, Hosmer added an RBI single to become MVP of the All-Star Game and the American League beat the Nationals 4-2 Tuesday night for its fourth straight win.

If the defending champion Royals reach the World Series for the third straight year, they will start at home, sweet, home once again.

“Hopefully this is something we can all rally upon for the second half and find a way to use that home-field advantage,” Hosmer said.

David Ortiz found himself in the middle of the most touching moment at Petco Park, embraced by his AL teammates near first base after exiting his final All-Star Game. The popular Big Papi plans to retire at 40 after this season with Boston.

Kris Bryant of the Cubs led the parade of sparkling young talent with a first-inning home run. The Yankees’ Dellin Betances flashed his 100 mph heat, and Astros reliever Will Harris came on to throw a called third strike past Cardinals rookie Aledmys Diaz on a 3-2 pitch on the outside corner with the bases loaded to end the eighth.

Royals reliever Kelvin Herrera pitched a hitless sixth for the AL, which will open the Series at home for the 11th time in 14 years since the All-Star winner has been used to determine the hosts for Games 1 and 2.

Kansas City became baseball royalty last fall, bursting to a 2-0 lead over the New York Mets at Kauffman Stadium, where Cueto pitched a two-hitter in the second game. The Royals won in five games for their first title since 1985.

This year, Kansas City is languishing at 45-43, seven games off the AL Central lead and in the middle of the wild-card race.

“We know how much that home-field advantage helped us,” Hosmer said. “It just brings that sense of comfort to the team and gives you a jumpstart for the whole Series.”

The team with home field has won the World Series six of the last seven times and 24 of the past 30.

Cleveland’s Corey Kluber pitched a 1-2-3 second inning for the win, and Zach Britton induced Nolan Arenado’s game-ending, double-play grounder for the save as the AL cut its deficit to 43-42 with two ties. The NL has outscored the AL overall, 360-359.

Ortiz wore spikes with gold-colored bottoms and matching batting gloves to mark his 10th All-Star selection and delivered the AL batting order to umpires at home plate.

He gave a pregame pep talk to his teammates, hit a smash down the first-base line that Anthony Rizzo snagged to rob him of a potential RBI double in the first and walked against Jose Fernandez in the third.

When Edwin Encarnacion came out to pinch run for him, Ortiz waved to the crowd and then spent his AL teammates came out of the dugout to exchange hugs as the crowd of 42,386 rose in tribute.

“I was supposed to hit a home run in my second at-bat. My boy told me he was going to throw me a fastball, and the first pitch was a changeup,” Ortiz said.

“Then 3-2 he threw me a slider and I’m like, `Are you trying to break my back?’ But he said it was the catcher’s fault.”

Fernandez admitted, “I couldn’t believe that I was actually pitching to him. We both looked at each other and smiled.”

“He signed the jersey I brought for him,” the 23-year-old Miami Marlins ace said.

The All-Star Game returned to San Diego for the first time since 1992 at Jack Murphy Stadium. Just before this first pitch, commissioner Rob Manfred joined Rod Carew, his family and the family of late Padres great Tony Gwynn and named the batting titles after the two Hall of Famers, giving Gwynn the NL honor and Carew the AL championship.

Gwynn died of salivary gland cancer two years ago at age 54.

Randy Jones threw out the ceremonial first pitch and former Padres All-Star closer Trevor Hoffman helped open, bringing the game ball to the mound from the bullpen accompanied by AC/DC’s “Hell’s Bells.”

With an NL ballpark hosting for the second year in a row in a streak of at least four, the AL wore white uniforms, hit last and used the Padres clubhouse on the first-base side. Ball boys in retro-style mustard-and-mud Padres uniforms lent a San Diego feel to Petco, which opened in 2004.

There was a home run on the game’s fourth pitch for the second straight year; Bryant connected on a 96 mph Chris Sale fastball with two outs as hitters swung early in the count to beat the shadows creeping in from the left-field corner in the late-afternoon start.