CLEMSON, S.C. — James Conner’s smile said it all — Pittsburgh was happy to once again shuffle up the national championship picture.

“Hey, sorry to do that. But we wanted this one bad,” said Conner, who had two touchdowns and ran for 132 yards in the Panthers’ 43-42 stunner over No. 3 Clemson on Saturday.

Conner’s 20-yard TD run with 5:17 left inched the Panthers into striking range and Chris Blewitt — after a kiss on the cheek from coach Pat Narduzzi — struck a perfect, 48-yard field goal with six seconds left for the winning points.

“We’ll remember this one forever,” Conner said.

So, too, will Clemson (9-1, 6-1 Atlantic Coast Conference) which saw its run at perfection halted.

It was the Panthers (6-4, 3-3) who made the critical plays.

When Clemson was driving for a touchdown already up 42-34, linebacker Saleem Brightwell picked off quarterback Deshaun Watson — his third interception — and returned it 70 yards to set up a 20-yard TD by Conner that drew Pitt within 42-40.

When Clemson attempted to run out the clock, the Panthers defense stuffed Wayne Gallman a yard short on third and fourth downs to take over near midfield with 58 seconds left.

“We had a chance to put the game away and they stopped us,” Clemson coach Dabo Swinney said.