Voting mostly along party lines, the U.S. Senate on Wednesday confirmed former Pennsylvania Health Secretary Rachel Levine to be the nation’s assistant secretary of health. She is the first openly transgender federal official to win Senate confirmation.

The final vote was 52-48. Republican Sens. Lisa Murkowski of Alaska and Susan Collins of Maine joined all Democrats in supporting Levine.

Levine had been serving as Pennsylvania’s top health official since 2017, and emerged as the public face of the state’s response to the coronavirus pandemic. She is expected to oversee Health and Human Services offices and programs across the U.S.

President Joe Biden cited Levine’s experience when he nominated her in January.

Levine “will bring the steady leadership and essential expertise we need to get people through this pandemic — no matter their ZIP code, race, religion, sexual orientation, gender identity or disability,” Biden said.