PORTAGE, Mich. — President Joe Biden toured a state-of-the art coronavirus vaccine plant Friday, intent on showcasing progress even as extreme winter weather across the U.S. handed his vaccination campaign its first major setback, delaying shipment of about 6 million doses and causing temporary closures of inoculation sites in many communities.

While acknowledging the weather is “slowing up the distribution,” Biden said at the Pfizer plant in Michigan that he believes “we’ll be approaching normalcy by the end of this year.” His speech melded a recitation of his administration’s accomplishments in its first month confronting the pandemic, a vigorous pitch for his $1.9 trillion COVID relief bill and criticism of his predecessor.

The disruptions caused by frigid temperatures, snow and ice have left the White House and states scrambling to make up lost ground as three days’ worth of vaccine shipments were temporarily delayed. Even the president’s trip to see Pfizer’s largest plant was pushed back a day due to a storm affecting the nation’s capital.

Biden has set a goal of administering 100 million shots in his administration’s first 100 days, and he said Friday that’s still on track and it’s only a beginning.