The NFL has seen major COVID-19 outbreaks for the Titans and Ravens. Big stars and coaches have been stricken by the disease. There have been plenty of scheduling adjustments.

The Titans had the NFL’s first outbreak that forced the first postponement and then rescheduling of a game this season. Their game against Pittsburgh moved from Oct. 4 to Oct. 25 and wiped out their bye week. Their outbreak affected 24 players and personnel and postponed a second game — against Buffalo — for two days to a rare Tuesday night on Oct. 13. Since then, they’ve had only two players placed on the reserve/COVID-19 list.

“What we dealt with was unfortunate, and we handled it the best that we felt like we could,” coach Mike Vrabel said. “Every team is different. Every situation is different. I’m proud of the fact that the past few cases that we had were isolated with zero close contacts, and that’s a testament to our players, our staff.”

An outbreak among the Ravens and staff followed an overtime loss to Tennessee on Nov. 22 and decimated Baltimore’s roster heading into a pivotal Thanksgiving rematch with the Steelers. The game was postponed to Sunday, then Tuesday, then Wednesday. When the Ravens got on the field they had gone 10 days without playing and were without several key players, including quarterback Lamar Jackson, the 2019 NFL MVP.

Baltimore lost 19-14. Coach John Harbaugh appreciated the play and effort of the backups on the thin offensive and defensive lines.

The NFL’s lone unbeaten team dealt with ripple effects of outbreaks elsewhere: moving the Titans and Ravens games, switching their bye week. The Steelers recently sent to the COVID-19 list a group that includes tight end Vance McDonald and running back James Conner.

The Patriots’ Week 4 matchup against the Chiefs was postponed a day after QB Cam Newton tested positive. New England’s game the following week against Denver was twice postponed following positive tests by several players, including star cornerback Stephon Gilmore. In essence, the Patriots lost their bye week.

Eight players have gone on the reserve/COVID-19 list, three assistant coaches have been infected — defensive coordinator Ed Donatell missed all of November and was hospitalized at one point with respiratory complications — plus GM John Elway and CEO Joe Ellis were infected.

Denver essentially lost its bye week because of New England’s issues, and last Sunday the Broncos lost to the Saints 31-3 without any quarterbacks. Starter Drew Lock, backup Brett Rypien and practice squad veteran Blake Bortles were deemed high-risk close contacts of No. 3 QB Jeff Driskel, who tested positive on Thanksgiving.

Las Vegas players, coaches and the organization have been fined more than $1.2 million and docked a sixth-round pick for COVID-19 violations.

The team practiced the entire week before the Tampa Bay game without the starting offensive line after tackle Trent Brown tested positive. The other four linemen returned the morning of the game and the Raiders lost 45-20. Defensive lineman Clelin Ferrell tested positive leading up to the Kansas City game, several other defensive starters missed practice as high-risk close contacts before most returned to play in the 35-31 loss.

The Saints were fined $500,000 and stripped of a seventh-round draft pick for repeated protocol violations.