SANTA CLARA, Calif. — Aaron Rodgers threw for 305 yards and four touchdowns and the Green Bay Packers overwhelmed the undermanned San Francisco 49ers 34-17 on Thursday night.

Rodgers connected on deep shots to Davante Adams and Marquez Valdes-Scantling, and a short toss to Marcedes Lewis in the first half to get the Packers (6-2) out to a 21-3 lead over the Niners (4-5).

It was quite a reversal from the two meetings last season when San Francisco outscored Green Bay by a combined 50-0 in the first halves on the way to lopsided wins in the regular season and NFC title game.

The rematch looked nothing like those games in part because the Niners were missing almost all their key pieces from the game because of injuries and a positive coronavirus test for receiver Kendrick Bourne that also sidelined three of his teammates for “high risk” contacts.

That left San Francisco without quarterback Jimmy Garoppolo (ankle), All-Pro tight end George Kittle (foot), NFC title game star running back Raheem Mostert (ankle), receivers Deebo Samuel (hamstring) and Brandon Aiyuk (COVID-19 list), left tackle Trent Williams (COVID-19 list) and key defenders Nick Bosa (knee), Dee Ford (back) and Richard Sherman (calf).