ARLINGTON, Texas — Baker Mayfield threw for two touchdowns, one of which was set up when Myles Garrett had a strip sack for the third straight game, and Cleveland held on for a 49-38 victory over Dallas to improve to 3-1 for the first time since 2001.

Jarvis Landry had his first career touchdown pass in the receiver's 100th career game, a 37-yard toss to Odell Beckham Jr. in Beckham's first multi-TD game with the Browns.

Beckham finished with his first three-score game in nearly five years, capped by a 50-yard run on a reverse after the Cowboys had cut a 41-14 deficit to three points with less than four minutes remaining. He had five catches for 81 yards and two scores.

The Browns ran for 307 yards and three touchdowns despite losing lead back Nick Chubb to a knee injury in the first quarter.

TAMPA, Fla. — Tom Brady threw for 369 yards and five touchdowns, all to different receivers, helping the Tampa Bay rally from a 17-point deficit to beat Los Angeles.Brady shrugged off throwing an early interception returned for a touchdown and the Bucs (3-1) won their third straight to stay in first place in the NFC South.

CHICAGO — Philip Rivers threw a touchdown pass on Indianapolis' first possession and the Colts shut down Nick Foles and Chicago.After Rivers connected with Mo Alie-Cox on a 13-yard score, the NFL's top-ranked defense took over.The Colts (3-1) kept the Bears (3-1) out of the end zone until Allen Robinson caught a 16-yard pass with 1:35 remaining.

INGLEWOOD, Calif. — Jared Goff hit Cooper Kupp for a 55-yard touchdown with 6:56 to play, and Los Angeles beat New York in a game marred by a postgame fight between Rams cornerback Jalen Ramsey and Giants receiver Golden Tate.Ramsey and Tate scuffled at midfield after the final whistle after a game filled with trash-talking between the two Nashville-area natives.

LAS VEGAS — Josh Allen threw for two touchdowns and rushed for another, leading Buffalo past Las Vegas.Buffalo is 4-0 for the first time in 12 years. The BIlls were 3-1 in 2019, when they made the playoffs, and they lead the AFC East now.

LANDOVER, Md. — Lamar Jackson ran for a 50-yard touchdown and threw for two scores in a bounce-back performance by the reigning NFL MVP and Baltimore, which took control early and beat Washington.

DETROIT — Drew Brees threw two touchdown passes to Tre'Quan Smith 2:19 apart in the second quarter, helping short-handed New Orleans overcome a 14-point deficit and beat Detroit.

CINCINNATI — Joe Mixon ran for 151 yards and two touchdowns and caught Joe Burrow's pass for another score as Cincinnati rolled up 505 yards to beat Jacksonville.

MIAMI — Russell Wilson threw for 360 yards and two touchdowns as Seattle beat Miami.The Seahawks (4-0) have scored 30 or more points in four consecutive games for the first time since 2015.

HOUSTON — Dalvin Cook ran for 130 yards and two touchdowns and Minnesota withstood a late rally from winless Houston.

CHARLOTTE, N.C. — Teddy Bridgewater threw for 276 yards and two touchdowns and ran for a score, and Carolina beat Arizona.The Panthers (2-2) scored touchdowns on their first four trips inside the Card's 20-yard line.