PITTSBURGH — Jared McCann scored twice, Matt Murray finished with 39 saves and the Pittsburgh Penguins handed the Boston Bruins their first regulation loss since January with a 4-2 victory on Sunday night.

Nick Bjugstad and Jake Guentzel also scored for the Penguins, who survived another late push by the Bruins.

David Krejci picked up his 19th of the season and John Moore got Boston within one when he scored with just over a minute to go. But the Bruins couldn’t complete the comeback, ending their 19-game point streak.

It was the first regulation loss for Krejci and company since Jan. 19 against the New York Rangers.

Jaroslav Halak made 33 stops, but Boston remained winless in Pittsburgh since December 2015.

The Bruins used the franchise’s longest point streak since the 1940-41 season to rise above the muddled portion of the Eastern Conference playoff race. Their six-week stretch included flashes of dominance and a flair for the dramatic. Boston arrived in Pittsburgh coming off a 6-0 homestand, one that culminated with last-minute victories over Florida and Ottawa.

Boston’s run came to an end against a team that seems to be gaining some momentum late in a bumpy and wildly uneven season, at least by Pittsburgh standards. Just 24 hours removed from a draining split with Columbus during a home-and-home series, the Penguins rode the legs of two of their newest acquisitions, a dash of brilliance from Sidney Crosby and Guentzel and another steady performance by Murray to their fifth win in their last seven games.

Bjugstad and McCann have been revelations since their arrival in a trade with Florida on Feb. 1, their presence giving Pittsburgh a jolt of both size and — in the 22-year-old McCann — youth.

Bjugstad needed just 93 seconds to give the Penguins the lead, fighting for position at the far post and redirecting a centering pass from Zach Aston-Reese by Halak for his fifth goal in 18 games with Pittsburgh, matching the total he put up in 32 games with the Panthers earlier this year.