PITTSBURGH — Adam Frazier hit a two-run homer off Milwaukee closer Corey Knebel with two outs in the ninth inning to lift the Pittsburgh Pirates to a 6-4 victory on Wednesday night.

The Pirates tied it in the eighth on a throwing error by Knebel then ended a seven-game losing streak when Frazier homered into the first row of seats in the right-field stands.

Jesus Aguilar and Domingo Santana homered for the Brewers but Milwaukee missed a chance to pull into a tie with Colorado for the NL’s second wild-card spot.

Knebel (1-2) had converted 21 straight save opportunities. Milwaukee lost for just the third time in its last 12 games.

Felipe Rivero (5-2) earned the victory in relief. Frazier finished 2 for 5 with four RBIs.

The Brewers are trying to lock up the franchise’s third playoff berth since 1982. The bullpen has keyed Milwaukee’s persistent chase and manager Craig Counsell didn’t hesitate when rookie starter Aaron Wilkerson ran into trouble in the third.

The Pirates ended a 21-inning scoreless drought when Frazier drilled a two-run triple and Marte followed with an RBI single to put them up 3-2, their first lead in nine days. It didn’t last.

The Brewers moved in front in the seventh thanks to another erratic performance by Tyler Glasnow.

Glasnow walked four of the six batters he faced, and Eric Thames’ RBI double tied the game. The Brewers reclaimed the lead when Pittsburgh reliever A.J. Schugel walked in the go-ahead run.

Knebel came on for a four-out save with tying run at second in the bottom of the eighth. Knebel got David Freese to hit a grounder, but Knebel’s throw to first sailed wide, allowing Andrew McCutchen to race home.