Sen. John McCain is pursued by reporters early this morning after casting a 'no' vote on a measure to repeal parts of former President Barack Obama's health care law.

WASHINGTON — Dealing a serious blow to President Donald Trump’s agenda, the Senate early today rejected a measure to repeal parts of former President Barack Obama’s health care law after a night of high suspense in the U.S. Capitol.

Unable to pass even a so-called “skinny repeal,” it was unclear if Senate Republicans could advance any health bill despite seven years of promises to repeal “ObamaCare.”

“This is clearly a disappointing moment,” said Senate Majority Leader Mitch McConnell, R-Ky. “I regret that our efforts were not enough, this time.”

“It’s time to move on,” he said.

McConnell put the health bill on hold and announced that the Senate would move onto other legislation next week.

Trump responded on Twitter: “3 Republicans and 48 Democrats let the American people down. As I said from the beginning, let ObamaCare implode, then deal. Watch!”

A key vote to defeat the measure was cast by Sen. John McCain, R-Ariz., who returned to the Senate this week after receiving a diagnosis of brain cancer. In an impassioned speech the day he returned, McCain had called for bipartisanship on major issues of national concern, and a return to the “regular order” of legislating by committee.

Three Republicans joined with all Democrats to reject the amendment, which would have repealed a mandate that most individuals get health insurance and would have suspended a requirement that large companies provide coverage to their employees. It would have also suspended a tax on medical devices and denied funding to Planned Parenthood for a year.

The final vote was 49-51. Republicans Lisa Murkowski of Alaska and Susan Collins of Maine joined McCain in voting no.

On Twitter, McCain said the repeal bill “fell short of our promise to repeal & replace ObamaCare w/ meaningful reform,” adding, “I hope we can rely on humility, cooperation & dependence on each other to better serve the people who elected us.”

The amendment was a last resort for Senate Republicans to pass something — anything — to trigger negotiations with the House.

“It’s time to turn the page,” said Senate Minority Leader Charles Schumer of New York. “We are not celebrating. We are relieved.”

Health and Human Services Secretary Tom Price said in a statement that the Trump administration would pursue its health care goals through regulation. “This effort will continue,” Price said. But insurers, hospitals, doctors, and consumer groups are pressing the administration to guarantee billions of dollars in disputed subsidies to help stabilize insurance markets.

McConnell had introduced a pared-down health care bill late Thursday that he hoped would keep alive Republican ambitions to repeal “ObamaCare.”

The Congressional Budget Office said the amendment would have increased the number of uninsured people by 16 million, the same problem that vexed all the “repeal and replace” measures Republicans have offered.