PITTSBURGH — The last time No. 13 Louisville saw Pittsburgh’s Jamel Artis, the senior forward put up 43 points and gamely led a second-half comeback that made a potential blowout compelling in the final moments.

Two weeks later, the rematch was equally compelling. For entirely different reasons.

Dominant from the opening tip, the Cardinals shut down Artis and the rest of the Panthers in a 106-51 hammering Tuesday night that set records and provided a stark contrast of teams sprinting in opposite directions.

Louisville (17-4, 5-3 Atlantic Coast Conference) seems to have steadied itself. Donovan Mitchell scored a career-high 29 points for the Cardinals, handing Pitt the second-worst loss in the program’s history.

The 55-point margin was the largest every by a road team in ACC play. Louisville held Pitt (12-8, 1-6) to 25 percent shooting (13 of 51) and never let the Panthers in it, something the Cardinals failed to do earlier this month when they led by 24 early in the second half before an Artis-led charge forced Louisville to hold on for an 85-80 victory.

Pitt went with no buckets for more than 12 minutes inthe first half as the Cardinals built a 37-13 lead.