LOS ANGELES — Garry Shandling died from a blood clot in his heart, coroner’s officials said Tuesday more than seven months after the comedian’s unexpected death.

A report by Los Angeles’ coroner’s officials released Tuesday states the fatal clot occurred after the comedian developed blood clots in his legs. The comedian had not been feeling well during a trip to Hawaii, the report stated. Shandling died March 24 after calling paramedics to his home.

Los Angeles coroner’s officials had delayed issuing their determination of what killed the 66-year-old until after a review of his medical records and toxicology tests were completed. The toxicology results found only a therapeutic amount of Xanax and some cold medication in his system.

In 1992, Shandling created his comic masterpiece with “The Larry Sanders Show.” As Larry, Shandling dug deep to confront his own demons, and did it brilliantly as the series teetered between dual realities: public and private; make-believe and painfully true. The HBO series ran until 1998.

Shandling had blurred the lines for a television comedy before, with his “It’s Garry Shandling Show,” in the 1980s. Actors on the Showtime sitcom routinely broke the fourth wall to speak directly to the audience.